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. 2019 Sep;15(5):1203-1216.
doi: 10.5114/aoms.2018.79565. Epub 2018 Nov 13.

Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus

Yun-Sheng Wang  1   2 , Jun Ye  2 , Xiao Yang  3 , Gui-Ping Zhang  3 , Yong-Hong Cao  2 , Rong Zhang  2 , Wu Dai  2 , Qiu Zhang  1
Affiliations

Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus

Yun-Sheng Wang et al. Arch Med Sci. 2019 Sep.

Abstract

Introduction: To investigate the serum retinol binding protein (RBP)-4, cystatin C (Cys C), homocysteine (HCY) and high-sensitivity C-reactive protein (hs-CRP) levels in newly diagnosed type 2 diabetes mellitus (NT2DM) patients, prediabetes mellitus (PDM) subjects and normal controls, as well as their correlation with clinical and laboratory indexes, such as blood pressure and lipoprotein.

Material and methods: A total of 242 subjects, including 141 NT2DM patients, 48 PDM subjects and 53 healthy controls, were recruited in the present study. Serum RBP-4, Cys C and hs-CRP concentrations were measured by enzyme-linked immunosorbent assay (ELISA). HCY concentration was determined by the chemical luminescence method.

Results: There were significant differences in Cys C and hs-CRP among NT2DM patients, PDM subjects and normal controls. In comparison to controls, there were significantly elevated Cys C and hs-CRP levels in PDM (both p < 0.001), and a significantly increased Cys C level in NT2DM (p < 0.001); however, there were no significant differences in Cys C and hs-CRP levels between NT2DM and PDM, and no significant differences of hs-CRP levels between NT2DM and normal controls. No significant differences of RBP-4 and HCY levels among NT2DM, PDM and normal control groups were observed.

Conclusions: Aberrant Cys C expression and its clinical associations in NT2DM suggest their important role in this disease.

Keywords: cystatin C; high-sensitivity C-reactive protein; homocysteine; retinol binding protein-4; type 2 diabetes mellitus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A – Receiver operating characteristic (ROC) curve analysis of Cys C for the discriminative ability of NT2DM patients versus healthy controls. B – Receiver operating characteristic (ROC) curve analysis of hs-CRP for the discriminative ability of NT2DM patients versus healthy controls
Figure 2
Figure 2
A – Receiver operating characteristic (ROC) curve analysis of Cys C for the discriminative ability of PDM subjects versus healthy controls. B – Receiver operating characteristic (ROC) curve analysis of hs-CRP for the discriminative ability of PDM subjects versus healthy controls
See this image and copyright information in PMC

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References

    1. Lin Y, Sun Z. Current views on type 2 diabetes. J Endocrinol. 2010;204:1–11. - PMC - PubMed
    1. Lehto S, Ronnemaa T, Haffner SM, Pyorala K, Kallio V, Laakso M. Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM. Diabetes. 1997;46:1354–9. - PubMed
    1. Svensson AM, Miftaraj M, Franzen S, Eliasson B. Clinical effects, cardiovascular and renal outcomes associated with rapid-acting insulin analogs among individuals with type 2 diabetes: a nation-wide observational cohort study. Clin Diabetes Endocrinol. 2017;3:5. - PMC - PubMed
    1. Sun X, He J, Ji XL, et al. Association of chronic kidney disease with coronary heart disease and stroke risks in patients with type 2 diabetes mellitus: an observational cross-sectional study in Hangzhou, China. Chin Med J (Engl) 2017;130:57–63. - PMC - PubMed
    1. Patti AM, Al-Rasadi K, Giglio RV, et al. Natural approaches in metabolic syndrome management. Arch Med Sci. 2018;14:422–41. - PMC - PubMed