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Review
. 2019 Nov:149:104465.
doi: 10.1016/j.phrs.2019.104465. Epub 2019 Sep 28.

The B side of rheumatoid arthritis pathogenesis

Stefano Alivernini  1 , Barbara Tolusso  2 , Anna Laura Fedele  2 , Clara Di Mario  3 , Gianfranco Ferraccioli  3 , Elisa Gremese  4
Affiliations
Review

The B side of rheumatoid arthritis pathogenesis

Stefano Alivernini et al. Pharmacol Res. 2019 Nov.

Abstract

In the last years, a dramatic amount of research has been performedincreasing the knowledge about the biological mechanism underpinning Rheumatoid Arthritis (RA) inflammation, putting B lymphocytes in the center of RA pathogenesis. Nowadays, B cell phenotypes and autoantibodies positivity arose as important biomarkers in early and long-standing disease. Moreover, comparative analysis of peripheral blood and synovial tissue compartments enables the identification of novel physiopathological mechanisms promoting inflammation. In this narrative review we will discuss the biological relevance of B cell derived autoimmunity and in RA course, from disease onset to remission achievement.

Keywords: Autoantibodies; B lymphocytes; Biomarkers; Peripheral Blood; Rheumatoid Arthritis; Synovial tissue.

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