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. 2019 Sep;98(39):e17311.
doi: 10.1097/MD.0000000000017311.

Immune infiltration in nasopharyngeal carcinoma based on gene expression

Meng-Si Luo  1 , Guan-Jiang Huang  2 , Bao-Xinzi Liu  3
Affiliations

Immune infiltration in nasopharyngeal carcinoma based on gene expression

Meng-Si Luo et al. Medicine (Baltimore). 2019 Sep.

Abstract

Immune infiltration of nasopharyngeal carcinoma (NPC) is closely associated with the patients' prognosis. However, previous studies have not interpreted the difference of infiltrating immune cells in NPC.We comprehensively analyzed the tumor-infiltrating immune cells present in NPC for the first time, which was based on a scientific deconvolution algorithm (CIBERSORT) and the gene expression data of GSE64634. The fractions of 22 immune cells were assessed to reveal the associations between normal samples and NPC samples.Profiles of immune infiltration vary significantly between normal samples and NPC samples, and the variation could characterize the individual differences. NPC samples contained a higher proportion for M1 macrophages, whereas memory B cells and CD4 memory resting T cells were relatively lower.Our data suggest that the differences in the infiltrating immune cells in NPC and these differences would probably facilitate patient consultation and individualized treatment.

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Conflict of interest statement

Disclosure: The authors have no finding and conflicts of interest to disclose. The authors are responsible for the content and writing of the paper.

Figures

Figure 1
Figure 1
The bar plot of immune infiltration between normal samples and NPC samples. NK = Natural killer.
Figure 2
Figure 2
Principal components analysis performed on normal samples and NPC samples.
Figure 3
Figure 3
Correlation matrix of all 22 immune cell proportions and immune cytolytic activity between normal samples and NPC samples.
Figure 4
Figure 4
The violin plot of the 22 immune cell proportions between normal samples and NPC samples.
Figure 5
Figure 5
Heat map of the 22 immune cell proportions between normal samples and NPC samples.
Figure 6
Figure 6
Survival analyses the significant tumor-infiltrating immune cells (A, CD4 memory resting T cells; B, M1 macrophages; C, memory B cells, and) in the TGGA database.
See this image and copyright information in PMC

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