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Comment
. 2019 Oct;9(10):1346-1348.
doi: 10.1158/2159-8290.CD-19-0839.

Bringing Oncohistones into the Fold

Jay F Sarthy  1   2 , Steven Henikoff  3   4
Affiliations
Comment

Bringing Oncohistones into the Fold

Jay F Sarthy et al. Cancer Discov. 2019 Oct.

Abstract

Identification of cancer-associated mutations in core histone genes has proved challenging due to these genes' highly conserved nature and presence in large arrays. Recent analyses of cancer genomes, including one in this issue of Cancer Discovery, show that mutations in the histone fold can affect nucleosome stability, providing a novel mechanism by which oncohistones contribute to tumorigenesis.See related article by Bennett et al., p. 1438.

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  • A Mutation in Histone H2B Represents a New Class of Oncogenic Driver.
    Bennett RL, Bele A, Small EC, Will CM, Nabet B, Oyer JA, Huang X, Ghosh RP, Grzybowski AT, Yu T, Zhang Q, Riva A, Lele TP, Schatz GC, Kelleher NL, Ruthenburg AJ, Liphardt J, Licht JD. Bennett RL, et al. Cancer Discov. 2019 Oct;9(10):1438-1451. doi: 10.1158/2159-8290.CD-19-0393. Epub 2019 Jul 23. Cancer Discov. 2019. PMID: 31337617 Free PMC article.

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