Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Oct 1;9(10):79.
doi: 10.1038/s41408-019-0244-2.

A novel machine-learning-derived genetic score correlates with measurable residual disease and is highly predictive of outcome in acute myeloid leukemia with mutated NPM1

Nikhil Patkar  1 , Anam Fatima Shaikh  2 , Chinmayee Kakirde  2 , Shrinidhi Nathany  2 , Hridya Ramesh  2 , Prasanna Bhanshe  2 , Swapnali Joshi  2 , Shruti Chaudhary  2 , Sadhana Kannan  3 , Syed Hasan Khizer  4 , Gaurav Chatterjee  2 , Prashant Tembhare  2 , Dhanalaxmi Shetty  5 , Anant Gokarn  4 , Sachin Punatkar  4 , Avinash Bonda  4 , Lingaraj Nayak  4 , Hasmukh Jain  4 , Navin Khattry  4 , Bhausaheb Bagal  4 , Manju Sengar  4 , Sumeet Gujral  2 , Papagudi Subramanian  2
Affiliations

A novel machine-learning-derived genetic score correlates with measurable residual disease and is highly predictive of outcome in acute myeloid leukemia with mutated NPM1

Nikhil Patkar et al. Blood Cancer J. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. A total of 389 somatic mutations were harbored among 110 patients.
The above circos plot (1 A) highlights the genomic complexity of NPM1-mutated AML. Commonly occurring gene mutations are colored. The scoring system is detailed in panel b. Clinical relevance of the machine-learning-derived genetic score for NPM1-mutated AML is also depicted here. The Kaplan–Meier plot in the top-right section (c) shows the clinical relevance of genetic risk when factored for overall survival (OS) and plot on the lower right (d) for relapse-free survival (RFS)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Thiede C, et al. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML) Blood. 2006;107:4011–4020. doi: 10.1182/blood-2005-08-3167. - DOI - PubMed
    1. Patel JL, et al. Coexisting and cooperating mutations in NPM1-mutated acute myeloid leukemia. Leuk. Res. 2017;56:7–12. doi: 10.1016/j.leukres.2017.01.027. - DOI - PubMed
    1. Shlush LI. Age-related clonal hematopoiesis. Blood. 2018;131:496–504. doi: 10.1182/blood-2017-07-746453. - DOI - PubMed
    1. Papaemmanuil E, et al. Genomic classification and prognosis in acute myeloid leukemia. N. Engl. J. Med. 2016;374:2209–2221. doi: 10.1056/NEJMoa1516192. - DOI - PMC - PubMed
    1. Libbrecht MW, Noble WS. Machine learning applications in genetics and genomics. Nat. Rev. Genet. 2015;16:321–332. doi: 10.1038/nrg3920. - DOI - PMC - PubMed

Publication types