Immunotherapy for head and neck cancer: where are we now and where are we going?
- PMID: 31576284
- PMCID: PMC6685871
- DOI: 10.21037/atm.2019.03.58
Immunotherapy for head and neck cancer: where are we now and where are we going?
Conflict of interest statement
Conflicts of interest: JM Bauml discloses research funding to his institution from Merck, Incyte, Carevive Systems, Novartis, Bayer, Janssen, Astra Zeneca and Takeda. He discloses that he has performed consultative services for Bristol Myers Squibb, Astra Zeneca, Celgene, Merck, Janssen, Genentech, Guardant Health, Boehringer Ingelheim and Takeda; C Aggarwal discloses research funding to her institution from Genentech/Roche, Incyte, Macrogenics and Medimmune. She has performed consultative services for Genentech, Bristol Myers Squibb, and Lilly. An immediate family member is on a speakers’ bureau with Genentech, Novartis, and Pfizer; RB Cohen discloses research funding to his institution from Merck, Celldex, Innate, Macrogenics, HEAT, Genocea, and Xencor. He discloses that he has performed consultative services for Takeda, HEAT, Innate, and Genocea.
Comment on
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Efficacy and safety of pembrolizumab in recurrent/metastatic head and neck squamous cell carcinoma: pooled analyses after long-term follow-up in KEYNOTE-012.Br J Cancer. 2018 Jul;119(2):153-159. doi: 10.1038/s41416-018-0131-9. Epub 2018 Jun 29. Br J Cancer. 2018. PMID: 29955135 Free PMC article. Clinical Trial.
References
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- Seiwert TY, Burtness B, Mehra R, et al. Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial. Lancet Oncol 2016;17:956-65. 10.1016/S1470-2045(16)30066-3 - DOI - PubMed
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- Chow LQM, Haddad R, Gupta S, et al. Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort. J Clin Oncol 2016;34:3838-45. 10.1200/JCO.2016.68.1478 - DOI - PMC - PubMed
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