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Editorial
. 2019 Jul;7(Suppl 3):S79.
doi: 10.21037/atm.2019.04.11.

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski  1 , Joseph B Moore 4th  1 , Shizuka Uchida  1   2
Affiliations
Editorial

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski et al. Ann Transl Med. 2019 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
VCAM-1+ macrophages guide hematopoietic stem/progenitor cell to sites of definitive hematopoiesis. Primitive hematopoiesis occurs at early somite stages in the ICM and the RBI. The ICM cell originate from the posterior LPM and differentiate into primitive erythrocytes, neutrophils, and thrombocytes; and the RBI cells are derived from the lateral mesoderm of the head and differentiate into macrophages. Subset of macrophages expressing ICAM-1 migrate to the sites of definitive hematopoiesis in AGM and CHT to recruit hematopoietic stem cells and initiate neonatal hematopoiesis and guide them further to sites of adult and definitive hematopoiesis in kidneys and thymus. ICM, intermediate cell mass; RBI, rostral blood island; LPM, lateral plate mesoderm; AGM, aorta-gonad-mesonephros; CHT, caudal hematopoietic tissue; VCAM-1, vascular cell adhesion molecule-1.
See this image and copyright information in PMC

Comment on

  • VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche.
    Li D, Xue W, Li M, Dong M, Wang J, Wang X, Li X, Chen K, Zhang W, Wu S, Zhang Y, Gao L, Chen Y, Chen J, Zhou BO, Zhou Y, Yao X, Li L, Wu D, Pan W. Li D, et al. Nature. 2018 Dec;564(7734):119-124. doi: 10.1038/s41586-018-0709-7. Epub 2018 Nov 19. Nature. 2018. PMID: 30455424 Free PMC article.

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