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Editorial
. 2019 Jul;7(Suppl 3):S116.
doi: 10.21037/atm.2019.05.48.

VCAM-1+ macrophages usher hematopoietic stem and progenitor cell to vascular niche "hotspots"

Yahui Grace Chiu  1 , Omar S Aljitawi  1
Affiliations
Editorial

VCAM-1+ macrophages usher hematopoietic stem and progenitor cell to vascular niche "hotspots"

Yahui Grace Chiu et al. Ann Transl Med. 2019 Jul.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Proposed model. HSPC entrance and retention in vascular niche “hotspots” is determined by HSPC VLA-4 and VCAM-1+ macrophage interactions and follows two main types of retention, type 1 and type 2. In type 1 VCAM-1+ macrophages guides HSPCs to enter the venous capillaries. In type 2, HSPCs interact with VCAM-1+ macrophages in CVP and then becomes surrounded by a pocket of endothelial cells. HSPC, hematopoietic stem and progenitor cell; VLA-4, integrin α4β1; VCAM-1, vascular cell adhesion molecule 1; CVP, caudal venous plexus.
See this image and copyright information in PMC

Comment on

  • VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche.
    Li D, Xue W, Li M, Dong M, Wang J, Wang X, Li X, Chen K, Zhang W, Wu S, Zhang Y, Gao L, Chen Y, Chen J, Zhou BO, Zhou Y, Yao X, Li L, Wu D, Pan W. Li D, et al. Nature. 2018 Dec;564(7734):119-124. doi: 10.1038/s41586-018-0709-7. Epub 2018 Nov 19. Nature. 2018. PMID: 30455424 Free PMC article.

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