Turning stem cells homing potential into cancer specific drug delivery machines

Nedime Serakinci^{1

2}, Huseyin Cagsin^{1

2}

Affiliations

¹ Department of Medical Genetics, Faculty of Medicine, Faculty of Art and Sciences, Near East University, Nicosia, Turkish Republic of Northern Cyprus.
² Department of Molecular Biology and Genetics, Faculty of Art and Sciences, Near East University, Nicosia, Turkish Republic of Northern Cyprus.

Editorial

Nedime Serakinci et al. Ann Transl Med. 2019 Jul.

. 2019 Jul;7(Suppl 3):S148.

doi: 10.21037/atm.2019.06.30.

Nedime Serakinci^{1

2}, Huseyin Cagsin^{1

2}

¹ Department of Medical Genetics, Faculty of Medicine, Faculty of Art and Sciences, Near East University, Nicosia, Turkish Republic of Northern Cyprus.
² Department of Molecular Biology and Genetics, Faculty of Art and Sciences, Near East University, Nicosia, Turkish Republic of Northern Cyprus.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer.
Schweizer MT, Wang H, Bivalacqua TJ, Partin AW, Lim SJ, Chapman C, Abdallah R, Levy O, Bhowmick NA, Karp JM, De Marzo A, Isaacs JT, Brennen WN, Denmeade SR. Schweizer MT, et al. Stem Cells Transl Med. 2019 May;8(5):441-449. doi: 10.1002/sctm.18-0230. Epub 2019 Feb 8. Stem Cells Transl Med. 2019. PMID: 30735000 Free PMC article. Clinical Trial.

1. Serakinci N, Christensen R, Fahrioglu U, et al. Mesenchymal stem cells as therapeutic delivery vehicles targeting tumor stroma. Cancer Biother Radiopharm 2011;26:767-73. 10.1089/cbr.2011.1024 - DOI - PubMed
1. Kortesidis A, Zannettino A, Isenmann S, et al. Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells. Blood 2005;105:3793-801. 10.1182/blood-2004-11-4349 - DOI - PubMed
1. Ries C, Egea V, Karow M, et al. MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines. Blood 2007;109:4055-63. 10.1182/blood-2006-10-051060 - DOI - PubMed
1. Honoki K, Tsujiuchi T. Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas. Expert Rev Anticancer Ther 2013;13:983-96. 10.1586/14737140.2013.820010 - DOI - PubMed
1. Christensen R, Alsner J, Brandt Sorensen F, et al. Transformation of human mesenchymal stem cells in radiation carcinogenesis: long-term effect of ionizing radiation. Regen Med 2008;3:849-61. 10.2217/17460751.3.6.849 - DOI - PubMed