Outcome of safety and efficacy of allogeneic mesenchymal stromal cell derived from umbilical cord for the treatment of osteoarthritis in a randomized blinded placebo-controlled trial

Kiran Shah^{1

2}, Huseyin Sumer¹

Affiliations

¹ Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University, Hawthorn, Australia.
² Magellan Stem Cells P/L, Box Hill North, Australia.

Editorial

Kiran Shah et al. Ann Transl Med. 2019 Jul.

. 2019 Jul;7(Suppl 3):S154.

doi: 10.21037/atm.2019.06.39.

Kiran Shah^{1

2}, Huseyin Sumer¹

¹ Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University, Hawthorn, Australia.
² Magellan Stem Cells P/L, Box Hill North, Australia.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial.
Matas J, Orrego M, Amenabar D, Infante C, Tapia-Limonchi R, Cadiz MI, Alcayaga-Miranda F, González PL, Muse E, Khoury M, Figueroa FE, Espinoza F. Matas J, et al. Stem Cells Transl Med. 2019 Mar;8(3):215-224. doi: 10.1002/sctm.18-0053. Epub 2018 Dec 28. Stem Cells Transl Med. 2019. PMID: 30592390 Free PMC article. Clinical Trial.

1. Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-7. 10.1080/14653240600855905 - DOI - PubMed
1. Caplan AI, Correa D. The MSC: an injury drugstore. Cell Stem Cell 2011;9:11-5. 10.1016/j.stem.2011.06.008 - DOI - PMC - PubMed
1. English K, Mahon BP. Allogeneic mesenchymal stem cells: agents of immune modulation. J Cell Biochem 2011;112:1963-8. 10.1002/jcb.23119 - DOI - PubMed
1. Trounson A, McDonald C. Stem Cell Therapies in Clinical Trials: Progress and Challenges. Cell Stem Cell 2015;17:11-22. 10.1016/j.stem.2015.06.007 - DOI - PubMed
1. Shah K, Zhao AG, Sumer H. New Approaches to Treat Osteoarthritis with Mesenchymal Stem Cells. Stem Cells Int 2018;2018:5373294. 10.1155/2018/5373294 - DOI - PMC - PubMed