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Review
. 2019 Nov;36(6):932-935.
doi: 10.1111/pde.14005. Epub 2019 Oct 2.

Cutaneous polyarteritis nodosa in pediatric patients successfully treated with TNF-α inhibitor and methotrexate: Case series and literature review

Ngan Do  1 , Sarah Ringold  2 , Heather Brandling-Bennett  3
Affiliations
Review

Cutaneous polyarteritis nodosa in pediatric patients successfully treated with TNF-α inhibitor and methotrexate: Case series and literature review

Ngan Do et al. Pediatr Dermatol. 2019 Nov.

Abstract

Cutaneous polyarteritis nodosa (CPAN) is a rare necrotizing vasculitis affecting small- to medium-sized arteries. Reported treatments include oral corticosteroids alone or in combination with non-steroidal antiinflammatory drugs, intravenous immunoglobulins, cyclophosphamide, azathioprine, colchicine, or dapsone. However, some patients with CPAN do not respond to such treatments and continue to experience exacerbations over prolonged periods. This series provides support for the use of TNF-α inhibitors in the treatment of recalcitrant CPAN in pediatric patients.

Keywords: TNF-alpha Inhibitor; cutaneous polyarteritis nodosa; vasculitis.

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References

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