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Review
. 2019 Sep 30;90(10-S):20-29.
doi: 10.23750/abm.v90i10-S.8751.

Cardiac conduction defects

Affiliations
Review

Cardiac conduction defects

Giulia Guerri et al. Acta Biomed. .

Abstract

Defects in cardiac electric impulse formation or conduction can lead to an irregular beat (arrhythmia) that can cause sudden death without any apparent cause or after stress. In the following sections, we describe the genetic disorders associated with primary cardiac conduction defects, primarily caused by mutations in ion channel genes. Primary indicates that these disorders are not caused by drugs and are not secondary to other disorders like cardiomyopathies (described in the next section).

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

References

    1. Brugada R, Campuzano O, Sarquella-Brugada G, et al. GeneReviews. Seattle (WA): University of Washington, Seattle; 2005. Brugada syndrome.
    1. Benito B, Brugada J, Brugada R, Brugada P. Brugada syndrome. Rev Esp Cardiol. 2009;62:1297–315. - PubMed
    1. Kapplinger JD, Tester DJ, Alders M, et al. An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. Heart Rhythm. 2010;7:33–46. - PMC - PubMed
    1. Crotti L, Kellen CA, Tester DJ, et al. Spectrum and prevalence of mutations involving BrS1-12-susceptibility genes in a cohort of unrelated patients referred for Brugada syndrome genetic testing: implications for genetic testing. J Am Coll Cardiol. 2012;60:1410–8. - PMC - PubMed
    1. Janin A, Bessière F, Georgescu T, Chanavat V, Chevalier P, Millat G. TRPM4 mutations to cause autosomal recessive and not autosomal dominant Brugada type 1 syndrome. Eur J Med Genet. 2018 - PubMed

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