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Review
. 2019 Sep 30;90(10-S):87-89.
doi: 10.23750/abm.v90i10-S.8766.

Mendelian non-syndromic obesity

Stefano Paolacci  1 , Giuseppe Pompucci, Barbara Paolini, Irene Del Ciondolo, Giacinto Abele Donato Miggiano, Barbara Aquilanti, Andrea Scaramuzza, Valeria Velluti, Giuseppina Matera, Lucilla Gagliardi, Matteo Bertelli
Affiliations
Review

Mendelian non-syndromic obesity

Stefano Paolacci et al. Acta Biomed. .

Abstract

Obesity is highly heritable and arises from the interplay of many genes and environmental factors. It can be defined as the result of prolonged imbalance between calorie intake and energy utilization. About 5% of cases of non-syndromic obesity are monogenic (Mendelian obesity). The amount of adipose tissue in the body is mainly regulated by leptin, a hormone produced by adipocytes, and Mendelian obesity is mainly caused by mutations that disrupt the leptin/melanocortin pathway. In this article, we summarize the genes involved in genetic obesity and the test we use for genetic analysis.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

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