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Review
. 2019 Sep 30;90(10-S):93-102.
doi: 10.23750/abm.v90i10-S.8768.

Molecular foundations of chiropractic therapy

Paolo Enrico Maltese  1 , Sandro Michelini, Manuela Baronio, Matteo Bertelli
Affiliations
Review

Molecular foundations of chiropractic therapy

Paolo Enrico Maltese et al. Acta Biomed. .

Abstract

Background and aim: Alternative medicine is a broad term used to encompass different therapies, including chiropractic. Chiropractic was called "a science of healing without drugs" by its founder, David Daniel Palmer. It is based on the idea that the body has a powerful self-healing ability and that there is a relationship between body structure and function that affects health. In particular, chiropractic assumes that the nervous system controls the human body through nerves branching from the vertebral column and spinal cord. Researchers do not fully understand how chiropractic therapies affect pain, but chiropractic is widely used today to treat chronic pain, such as back pain. Different studies with animal models have demonstrated that chiropractic therapies mediate neuroplasticity, specifically through modulation of neurotrophins. No studies have yet been published on interaction between neurotrophin gene polymorphisms and chiropractic treatment.

Methods: We searched PubMed with the following keywords: chiropractic, neuroplasticity, neurotrophin gene polymorphism for a panorama of on the molecular mechanisms of chiropractic therapy.

Results: From the material collected, we identified a set of genes and some functional polymorphisms that could be correlated with better response to chiropractic therapy.

Conclusions: Further association studies will be necessary to confirm hypotheses of a correlation between single nucleotide polymorphisms in specific genes and better response to chiropractic therapy.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

Figures

Figure 1.
Figure 1.
Presence of specific SNPs in genes related to brain function could increase production of neurotrophins (NTs) by neurons and consequently their neuroplasticity, leading to a better response to chiropractic therapy through regulation of development, maintenance and function of the vertebrate nervous system. These specific SNPs could also increase IGF-1 blood levels after stimulation by massage
See this image and copyright information in PMC

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