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. 2019 Oct 3;381(14):1387-1389.
doi: 10.1056/NEJMc1903013.

Longer-Term Outcomes of HIV-Positive-to-HIV-Positive Renal Transplantation

Philippe Selhorst  1 , Catharina E Combrinck  1 , Kathryn Manning  2 , Francois C J Botha  1 , Jan P L Labuschagne  1 , Colin Anthony  1 , David L Matten  1 , Autumn Breaud  3 , William Clarke  3 , Thomas C Quinn  4 , Andrew D Redd  5 , Carolyn Williamson  6 , Elmi Muller  6
Affiliations

Longer-Term Outcomes of HIV-Positive-to-HIV-Positive Renal Transplantation

Philippe Selhorst et al. N Engl J Med. .
No abstract available

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Figures

Figure 1.
Figure 1.. Clinical Outcomes and HIV Superinfection in HIV-Positive–to–HIV-Positive Renal Transplantation.
Panel A shows the Kaplan–Meier curve for graft survival (with data from patients who died with a functioning graft censored at the time of death), and Panel B, the Kaplan–Meier curve for patient survival after transplantation. Panel C shows the percentage identity between the proviral V3 DNA sequences (derived from the peripheral-blood mononuclear cell samples from 25 recipients) and their closest matching viral sequences in the respective donors. The dashed line indicates the level of percentage identity in the V3 region below which 99% of any two subtype C viruses from the Los Alamos National Laboratory 2017 reference panel would fall when compared (https://www.hiv.lanl.gov). Percentage identity above this level indicates a likely donor superinfection. Results in positive and negative controls are shown on the left. In most cases, there were two recipients (indicated by orange or blue dots and text) per donor (indicated in black text).
See this image and copyright information in PMC

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