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Comment
. 2019 Oct 1;30(4):621-623.
doi: 10.1016/j.cmet.2019.08.022.

Bone Marrow: An Immunometabolic Refuge during Energy Depletion

Emily L Goldberg  1 , Vishwa Deep Dixit  2
Affiliations
Free article
Comment

Bone Marrow: An Immunometabolic Refuge during Energy Depletion

Emily L Goldberg et al. Cell Metab. .
Free article

Abstract

An integrated immunometabolic response during negative energy balance is required for host survival. Three new papers by Jordan et al. (2019), Nagai et al. (2019), and Collins et al. (2019) report that monocytes, naive B cells, and memory CD8 T cells use bone marrow as a haven to tide off periods of metabolic adversity to maintain immune-responsiveness.

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  • Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses.
    Nagai M, Noguchi R, Takahashi D, Morikawa T, Koshida K, Komiyama S, Ishihara N, Yamada T, Kawamura YI, Muroi K, Hattori K, Kobayashi N, Fujimura Y, Hirota M, Matsumoto R, Aoki R, Tamura-Nakano M, Sugiyama M, Katakai T, Sato S, Takubo K, Dohi T, Hase K. Nagai M, et al. Cell. 2019 Aug 22;178(5):1072-1087.e14. doi: 10.1016/j.cell.2019.07.047. Cell. 2019. PMID: 31442401
  • The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
    Collins N, Han SJ, Enamorado M, Link VM, Huang B, Moseman EA, Kishton RJ, Shannon JP, Dixit D, Schwab SR, Hickman HD, Restifo NP, McGavern DB, Schwartzberg PL, Belkaid Y. Collins N, et al. Cell. 2019 Aug 22;178(5):1088-1101.e15. doi: 10.1016/j.cell.2019.07.049. Cell. 2019. PMID: 31442402 Free PMC article.
  • Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool.
    Jordan S, Tung N, Casanova-Acebes M, Chang C, Cantoni C, Zhang D, Wirtz TH, Naik S, Rose SA, Brocker CN, Gainullina A, Hornburg D, Horng S, Maier BB, Cravedi P, LeRoith D, Gonzalez FJ, Meissner F, Ochando J, Rahman A, Chipuk JE, Artyomov MN, Frenette PS, Piccio L, Berres ML, Gallagher EJ, Merad M. Jordan S, et al. Cell. 2019 Aug 22;178(5):1102-1114.e17. doi: 10.1016/j.cell.2019.07.050. Cell. 2019. PMID: 31442403 Free PMC article.

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