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Comment
. 2019 Oct 1;27(10):1483-1484.
doi: 10.1016/j.str.2019.09.002.

The More the Merrier: When Four Interfaces Are Better Than One

Alba Guarné  1
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Comment

The More the Merrier: When Four Interfaces Are Better Than One

Alba Guarné. Structure. .
Free article

Abstract

In this issue of Structure, Zhou et al. (2019) determine the crystal and solution structures of iASPP bound to PP1. The proteins interact through a discontinuous interface defined by four contact points. Association/dissociation of individual contacts enables the transition between multiple conformations and provides mechanistic insight into how ASPPs regulate phosphorylation of p53.

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  • Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
    Zhou Y, Millott R, Kim HJ, Peng S, Edwards RA, Skene-Arnold T, Hammel M, Lees-Miller SP, Tainer JA, Holmes CFB, Glover JNM. Zhou Y, et al. Structure. 2019 Oct 1;27(10):1485-1496.e4. doi: 10.1016/j.str.2019.07.012. Epub 2019 Aug 8. Structure. 2019. PMID: 31402222 Free PMC article.

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