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Comparative Study
. 2020 Feb;40(2):324-329.
doi: 10.1038/s41372-019-0513-8. Epub 2019 Oct 2.

Comparison of 'post-patent ductus arteriosus ligation syndrome' in premature infants after surgical ligation vs. percutaneous closure

Ryan M Serrano  1 , Mackenzie Madison  1 , Diane Lorant  2 , Mark Hoyer  1 , Ryan Alexy  3   4
Affiliations
Comparative Study

Comparison of 'post-patent ductus arteriosus ligation syndrome' in premature infants after surgical ligation vs. percutaneous closure

Ryan M Serrano et al. J Perinatol. 2020 Feb.

Abstract

Objective: To compare the incidence of post-PDA ligation syndrome after surgical vs. percutaneous closure of PDAs in very low birth weight (VLBW) infants.

Study design: Cohort study comparing 59 infants who underwent surgical ligation with 25 infants who underwent percutaneous closure. Comparisons between groups were made using two-sample t-tests and a Fisher's exact test. Comparisons of pre vs. post variables within each group were made using paired t-tests.

Results: Patients who underwent surgical ligation had a higher need for initiation of post-procedure hemodynamic support (12/59 vs. 0/24, p = 0.016), a higher post-procedure peak FiO2 (0.64 vs. 0.43, p = 0.004), and a larger absolute change in peak FiO2 (0.23 vs. 0.09, p = 0.008).

Conclusion: VLBW infants who had percutaneous closure of their PDA did not experience post ligation syndrome and had less escalation of respiratory support compared with infants who underwent surgical ligation.

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