A standardised diagnostic approach to pituitary neuroendocrine tumours (PitNETs): a European Pituitary Pathology Group (EPPG) proposal

C Villa^{1

2

3}, A Vasiljevic^{4

5

6

7}, M L Jaffrain-Rea^{8

9}, O Ansorge¹⁰, S Asioli^{11

12}, V Barresi¹³, L Chinezu¹⁴, M P Gardiman¹⁵, A Lania¹⁶, A M Lapshina¹⁷, L Poliani¹⁸, L Reiniger¹⁹, A Righi²⁰, W Saeger²¹, J Soukup²², M Theodoropoulou²³, S Uccella²⁴, J Trouillas^{4

5}, F Roncaroli²⁵

Affiliations

¹ Department of Pathological Cytology and Anatomy, Foch Hospital, 40 rue Worth, 92151, Suresnes, France. cm.villa@hopital-foch.org.
² INSERM U1016, CNRS UMR 8104, Cochin Institute, Paris Descartes University, 24 rue du faubourg Saint Jacques, 75014, Paris, France. cm.villa@hopital-foch.org.
³ Department of Endocrinology, CHU de Liège, University of Liège, Sart Tilman B35, 4000, Liège, Belgium. cm.villa@hopital-foch.org.
⁴ Université de Lyon 1, Université de Lyon, F-69000, Lyon, France.
⁵ Faculté de Médecine Lyon-Est, F-69372, Lyon, France.
⁶ Centre de Recherche en Cancérologie de Lyon (CRCL), INSERM U1052, CNRS UMR5286, Université de Lyon, Lyon, France.
⁷ Centre de Pathologie et de Neuropathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France.
⁸ Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
⁹ Neuromed Institute, IRCCS, Pozzilli, Italy.
¹⁰ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
¹¹ Department of Biomedical and Neuromuscular Sciences, Section of Anatomic Pathology 'M. Malpighi' at Bellaria Hospital, University of Bologna, Bologna, Italy.
¹² Pituitary Unit - Center for the Diagnosis and Treatment of Hypothalamic and Pituitary Diseases, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
¹³ Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
¹⁴ Department of Histology, Pharmacy, Sciences and Technology of Tirgu Mures, University of Medicine, Târgu Mureș, Romania.
¹⁵ Department of Medicine DIMED, Surgical Pathology & Cytopathology Unit, University Hospital of Padova, Padova, Italy.
¹⁶ Endocrinology Unit, Department of Biomedical Sciences, Humanitas University and Humanitas Research Hospital, Rozzano, Italy.
¹⁷ Department of Fundamental Pathomorphology, Endocrine Research Center, Ministry of Health of Russia, Moscow, Russia.
¹⁸ Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
¹⁹ 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
²⁰ Department of Pathology, Rizzoli Institute, Bologna, Italy.
²¹ Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
²² The Fingerland Department of Pathology, University Hospital and Faculty of Medicine, Hradec Kralove, Charles University, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
²³ Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany.
²⁴ Unit of Pathology, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
²⁵ Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

PMID: 31578606
DOI: 10.1007/s00428-019-02655-0

Review

A standardised diagnostic approach to pituitary neuroendocrine tumours (PitNETs): a European Pituitary Pathology Group (EPPG) proposal

C Villa et al. Virchows Arch. 2019 Dec.

. 2019 Dec;475(6):687-692.

doi: 10.1007/s00428-019-02655-0. Epub 2019 Oct 2.

Authors

Affiliations

¹ Department of Pathological Cytology and Anatomy, Foch Hospital, 40 rue Worth, 92151, Suresnes, France. cm.villa@hopital-foch.org.
² INSERM U1016, CNRS UMR 8104, Cochin Institute, Paris Descartes University, 24 rue du faubourg Saint Jacques, 75014, Paris, France. cm.villa@hopital-foch.org.
³ Department of Endocrinology, CHU de Liège, University of Liège, Sart Tilman B35, 4000, Liège, Belgium. cm.villa@hopital-foch.org.
⁴ Université de Lyon 1, Université de Lyon, F-69000, Lyon, France.
⁵ Faculté de Médecine Lyon-Est, F-69372, Lyon, France.
⁶ Centre de Recherche en Cancérologie de Lyon (CRCL), INSERM U1052, CNRS UMR5286, Université de Lyon, Lyon, France.
⁷ Centre de Pathologie et de Neuropathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France.
⁸ Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
⁹ Neuromed Institute, IRCCS, Pozzilli, Italy.
¹⁰ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
¹¹ Department of Biomedical and Neuromuscular Sciences, Section of Anatomic Pathology 'M. Malpighi' at Bellaria Hospital, University of Bologna, Bologna, Italy.
¹² Pituitary Unit - Center for the Diagnosis and Treatment of Hypothalamic and Pituitary Diseases, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
¹³ Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
¹⁴ Department of Histology, Pharmacy, Sciences and Technology of Tirgu Mures, University of Medicine, Târgu Mureș, Romania.
¹⁵ Department of Medicine DIMED, Surgical Pathology & Cytopathology Unit, University Hospital of Padova, Padova, Italy.
¹⁶ Endocrinology Unit, Department of Biomedical Sciences, Humanitas University and Humanitas Research Hospital, Rozzano, Italy.
¹⁷ Department of Fundamental Pathomorphology, Endocrine Research Center, Ministry of Health of Russia, Moscow, Russia.
¹⁸ Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
¹⁹ 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
²⁰ Department of Pathology, Rizzoli Institute, Bologna, Italy.
²¹ Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
²² The Fingerland Department of Pathology, University Hospital and Faculty of Medicine, Hradec Kralove, Charles University, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
²³ Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany.
²⁴ Unit of Pathology, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
²⁵ Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

PMID: 31578606
DOI: 10.1007/s00428-019-02655-0

Abstract

The 2017 World Health Organization (WHO) classification proposes to type and subtype primary adenohypophyseal tumours according to their cell lineages with the aim to establish more uniform tumour groups. The definition of atypical adenoma was removed in favour of high-risk adenoma, and the assessment of proliferative activity and invasion was recommended to diagnose aggressive tumours. Recently, the International Pituitary Pathology Club proposed to replace adenoma with the term of pituitary neuroendocrine tumour (PitNET) to better reflect the similarities between adenohypophyseal and neuroendocrine tumours of other organs. The European Pituitary Pathology Group (EPPG) endorses this terminology and develops practical recommendations for standardised reports of PitNETs that are addressed to histo- and neuropathologists. This brief report presents the results of EPPG's consensus for the reporting of PitNETs and proposes a diagnostic algorithm.

Keywords: European Pituitary Pathology Group; Pituitary neuroendocrine tumours; Standardised diagnostic approach.

PubMed Disclaimer

References

1. Eur J Endocrinol. 2015 Jun;172(6):791-801 - PubMed
1. Arch Pathol Lab Med. 2015 Mar;139(3):356-72 - PubMed
1. Mod Pathol. 2018 Dec;31(12):1770-1786 - PubMed
1. Nat Rev Endocrinol. 2018 Dec;14(12):705-720 - PubMed
1. Acta Neuropathol. 2013 Jul;126(1):123-35 - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A standardised diagnostic approach to pituitary neuroendocrine tumours (PitNETs): a European Pituitary Pathology Group (EPPG) proposal

Affiliations

A standardised diagnostic approach to pituitary neuroendocrine tumours (PitNETs): a European Pituitary Pathology Group (EPPG) proposal

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical