doi: 10.1007/BF03029155.
Idiotypic-antiidiotypic interactions in man
- PMID: 3158061
- DOI: 10.1007/BF03029155
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Idiotypic-antiidiotypic interactions in man
Ric Clin Lab.
1985 Jan-Mar.
Abstract
Anti-idiotypic (anti-Id) antibodies are directed against antigenic determinants expressed by the antigen-binding region of the immunoglobulin molecules. Their interaction with antigen receptors on immune cells modulates the immune response. In man auto-anti-Id antibodies have been demonstrated. These antibodies not only participate in the regulation of the immune response, but can result in disease as in the case of acquired angioedema with B cell malignancy and possibly in autoimmune diseases. Anti-Id antibodies may be useful tools in cancer immunotherapy and in the production of vaccines.
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