Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Nov;38(11):1178-1187.
doi: 10.1089/dna.2019.4852. Epub 2019 Oct 3.

Molecular Basis Underlying Host Immunity Subversion by Mycobacterium tuberculosis PE/PPE Family Molecules

Xiaowen Yu  1 , Jing Feng  1 , Lu Huang  2 , Hongyan Gao  1 , Jinkun Liu  1 , Shutong Bai  1 , Bin Wu  1 , Jianping Xie  3
Affiliations
Review

Molecular Basis Underlying Host Immunity Subversion by Mycobacterium tuberculosis PE/PPE Family Molecules

Xiaowen Yu et al. DNA Cell Biol. 2019 Nov.

Abstract

Mycobacterium tuberculosis proline-glutamic acid (PE)/proline-proline-glutamic acid (PPE) family proteins, with >160 members, are crucial for virulence, cell wall, host cell fate, host Th1/Th2 balance, and CD8+ T cell recognition. Ca2+ signaling is involved in PE/PPE protein-mediated host-pathogen interaction. PE/PPE proteins also function in heme utilization and nitric oxide production. PE/PPE family proteins are intensively pursued as diagnosis biomarkers and vaccine components.

Keywords: Mycobacterium tuberculosis; PE/PPE proteins; diagnosis biomarker; host immunity; vaccine.

PubMed Disclaimer

MeSH terms

LinkOut - more resources