Photodynamic Therapy: A Brief History
- PMID: 31581613
- PMCID: PMC6832404
- DOI: 10.3390/jcm8101581
Photodynamic Therapy: A Brief History
Abstract
Photodynamic therapy (PDT) involves the selective sensitization of tissues to light. A major advance in the field occurred when Thomas Dougherty at the Roswell Park Cancer Institute initiated a series of clinical studies that eventually led to FDA approval of the procedure. This report contains a summary of Dougherty's contributions and an assessment of where this has led, along with a summary of implications for future drug development.
Keywords: dougherty; hematoporphyrin derivative; photodynamic therapy; photofrin.
Conflict of interest statement
The author declares no conflict of interest.
References
-
- Raab O. Uber die Wirkung, fluorescirender Stoffe auf infusorien. Z. Biol. 1900;39:524–546.
-
- von Tappeiner H., Jodlbauer A. Über die Wirkung der photodynamischen (fluorescierenden) Stoffe auf Protozoen und Enzyme. Dtsch. Arch. Klin. Med. 1904;39:427–487.
-
- Lipson R.L., Baldes E.J., Olsen A.M. Hematoporphyrin derivative: A new aid for endoscopic detection of malignant disease. J. Thorac. Cardiovasc. Surg. 1961;42:623–629. - PubMed
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