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Comment
. 2019 Dec 1;25(23):6893-6895.
doi: 10.1158/1078-0432.CCR-19-2774. Epub 2019 Oct 3.

ctDNA in Gastric and Gastroesophageal Cancer: Prognostic, Predictive, or Preliminary?

Alexander M Frankell  1 , Elizabeth C Smyth  2
Affiliations
Comment

ctDNA in Gastric and Gastroesophageal Cancer: Prognostic, Predictive, or Preliminary?

Alexander M Frankell et al. Clin Cancer Res. .

Abstract

In gastric and gastroesophageal adenocarcinoma, circulating tumor DNA identifies molecular drivers missed using routine tumor biopsy, can refine patient selection for targeted therapy, and may be prognostic following surgical resection. However, lack of standardization could impede adoption of this technology as a clinically useful tool; prospective validation in clinical trials is required.See related article by Maron et al., p. 7098.

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  • Circulating Tumor DNA Sequencing Analysis of Gastroesophageal Adenocarcinoma.
    Maron SB, Chase LM, Lomnicki S, Kochanny S, Moore KL, Joshi SS, Landron S, Johnson J, Kiedrowski LA, Nagy RJ, Lanman RB, Kim ST, Lee J, Catenacci DVT. Maron SB, et al. Clin Cancer Res. 2019 Dec 1;25(23):7098-7112. doi: 10.1158/1078-0432.CCR-19-1704. Epub 2019 Aug 19. Clin Cancer Res. 2019. PMID: 31427281 Free PMC article.

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