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Comment
. 2019 Dec;16(12):725-726.
doi: 10.1038/s41571-019-0285-2.

Why BRCA mutations are not tumour-agnostic biomarkers for PARP inhibitor therapy

Nicola J Curtin  1 , Yvette Drew  2 , Sweta Sharma-Saha  2
Affiliations
Comment

Why BRCA mutations are not tumour-agnostic biomarkers for PARP inhibitor therapy

Nicola J Curtin et al. Nat Rev Clin Oncol. 2019 Dec.
No abstract available

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Comment on

  • Tumour lineage shapes BRCA-mediated phenotypes.
    Jonsson P, Bandlamudi C, Cheng ML, Srinivasan P, Chavan SS, Friedman ND, Rosen EY, Richards AL, Bouvier N, Selcuklu SD, Bielski CM, Abida W, Mandelker D, Birsoy O, Zhang L, Zehir A, Donoghue MTA, Baselga J, Offit K, Scher HI, O'Reilly EM, Stadler ZK, Schultz N, Socci ND, Viale A, Ladanyi M, Robson ME, Hyman DM, Berger MF, Solit DB, Taylor BS. Jonsson P, et al. Nature. 2019 Jul;571(7766):576-579. doi: 10.1038/s41586-019-1382-1. Epub 2019 Jul 10. Nature. 2019. PMID: 31292550 Free PMC article.

References

    1. Bryant, H. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913–917 (2005). - DOI
    1. Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917–921 (2005). - DOI
    1. Fong, P. C. et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 361, 123–134 (2009). - DOI
    1. Jonsson, P. et al. Tumour lineage shapes BRCA-mediated phenotypes. Nature 571, 576–579 (2019). - DOI
    1. Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011). - DOI

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