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. 2019 Sep 27;11(3):7056.
doi: 10.4081/hr.2019.7056. eCollection 2019 Sep 18.

Increased platelets count in HIV-1 uninfected infants born from HIV-1 infected mothers

Anicet Christel Maloupazoa Siawaya  1 , Amandine Mveang-Nzoghe  1 , Chérone Nancy Mbani Mpega  2 , Marielle Leboueny  1 , Ofilia Mvoundza Ndjindji  1 , Armel Mintsa Ndong  3 , Paulin N Essone  1   4 , Joel Fleury Djoba Siawaya  1
Affiliations

Increased platelets count in HIV-1 uninfected infants born from HIV-1 infected mothers

Anicet Christel Maloupazoa Siawaya et al. Hematol Rep. .

Abstract

HIV-exposed uninfected infants (HEU) represent a growing population in developing countries including Gabon. Several studies have shown the vulnerability of these infants toward infectious diseases. The aim of the study was to contribute to the global effort to understand how HIVexposure or anti retroviral therapy affects infants' blood elements. We assessed HEU infants' complete blood count using a blood analyzer instrument. Our investigations showed that among the observed clinically relevant hematological abnormalities events, thrombocytosis was the most prevalent clinically relevant hematological abnormality associated with HEU infants'. We showed that HEU infants had significantly higher platelets count than HUinfants. Therefore, higher level of platelets seems to characterize HEU infants when compared to HU infants.

Keywords: HIV-exposed; Platelets; blood cells.

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Conflict of interest statement

Conflict of interest: the authors declare no potential conflict of interest.

Figures

Figure 1.
Figure 1.
Platelets count in HIV-exposed uninfected (HEU) and HIV unexposed (HU) infants. The platelets count was significantly higher in HEU infants than HU infants (P=0.01). The observed difference was physiologically and clinically relevant.
Figure 2.
Figure 2.
HIV-exposed uninfected (HEU) and HIV unexposed (HU) infants' mean platelet volume: the mean platelet volume (MPV) was significantly lower in HEU infants than HU infants (P=0.04). The observation has no physiological significance as HEU MVPs is within normal range (6-11.1 fl).
See this image and copyright information in PMC

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