doi: 10.1016/0006-291x(85)90121-4.
Phorbolesters enhance basal D-glucose transport but inhibit insulin stimulation of D-glucose transport and insulin binding in isolated rat adipocytes
- PMID: 3158314
- DOI: 10.1016/0006-291x(85)90121-4
Item in Clipboard
Phorbolesters enhance basal D-glucose transport but inhibit insulin stimulation of D-glucose transport and insulin binding in isolated rat adipocytes
Biochem Biophys Res Commun.
.
Abstract
The C-kinase activating phorbolester TPA (12-O-Tetradecanoyl-beta-phorbol-13-acetate) and PdBu (4-beta-Phorbol-12,13,dibutyrate) stimulated D-glucose transport twofold in isolated rat adipocytes but inhibited high affinity insulin binding and the responsiveness of D-glucose transport to insulin stimulation by about 30%. Phorbolesters have therefore insulin-like effects but antagonize insulin on receptor and postreceptor level.
Similar articles
-
Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding.Biochem J. 1985 Jan 15;225(2):523-7. doi: 10.1042/bj2250523. Biochem J. 1985. PMID: 3883992 Free PMC article.
-
Tumor-promoting phorbol esters increase the Km of the ATP-binding site of the insulin receptor kinase from rat adipocytes.J Biol Chem. 1986 Mar 15;261(8):3869-75. J Biol Chem. 1986. PMID: 3005303
-
Rapid effects of phorbol esters on isolated rat adipocytes. Relationship to the action of protein kinase C.Eur J Biochem. 1985 May 2;148(3):407-12. doi: 10.1111/j.1432-1033.1985.tb08854.x. Eur J Biochem. 1985. PMID: 3158518
-
Role of kinases in insulin stimulation of glucose transport.J Membr Biol. 1989 Oct;111(1):1-23. doi: 10.1007/BF01869205. J Membr Biol. 1989. PMID: 2553978 Review. No abstract available.
-
Insulin-receptor interaction in isolated fat cells.Adv Enzyme Regul. 1970;8:219-38. doi: 10.1016/0065-2571(70)90019-1. Adv Enzyme Regul. 1970. PMID: 4320026 Review. No abstract available.
Cited by
-
Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice.Biochem J. 1989 Feb 15;258(1):141-6. doi: 10.1042/bj2580141. Biochem J. 1989. PMID: 2649084 Free PMC article.
-
Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes.Proc Natl Acad Sci U S A. 1989 Jun;86(12):4705-9. doi: 10.1073/pnas.86.12.4705. Proc Natl Acad Sci U S A. 1989. PMID: 2660145 Free PMC article.
-
The translocation of the glucose transporter sub-types GLUT1 and GLUT4 in isolated fat cells is differently regulated by phorbol esters.Biochem J. 1991 May 1;275 ( Pt 3)(Pt 3):597-600. doi: 10.1042/bj2750597. Biochem J. 1991. PMID: 2039438 Free PMC article.
-
Effect of protein kinase C activation and depletion on insulin stimulation of glycogen synthesis in cultured hepatoma cells.Experientia. 1988 Jan 15;44(1):34-7. doi: 10.1007/BF01960235. Experientia. 1988. PMID: 3280335
-
Protein kinase C is not required for insulin stimulation of hexose uptake in muscle cells in culture.Biochem J. 1987 Feb 15;242(1):131-6. doi: 10.1042/bj2420131. Biochem J. 1987. PMID: 3297042 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
