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. 1985 May;51(5):665-9.
doi: 10.1038/bjc.1985.100.

Treatment of malignant hypercalcaemia with clodronate

R C Percival, A D Paterson, A J Yates, D J Beard, D L Douglas, F E Neal, R G Russell, J A Kanis
Free PMC article

Treatment of malignant hypercalcaemia with clodronate

R C Percival et al. Br J Cancer. 1985 May.
Free PMC article

Abstract

We have assessed the effects of clodronate (dichloromethylene diphosphonate; Cl2MDP 0.8-3.2g daily by mouth for up to 3 months) in 17 episodes of hypercalcaemia and osteolysis due to carcinoma. Clodronate reduced serum calcium in 14 episodes and bone resorption in all patients. These remained suppressed for the duration of treatment, but recurred promptly when treatment was stopped. Clodronate may be a useful measure for controlling hypercalcaemia and osteolysis in patients with carcinoma.

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