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. 2020 Jan 30;100(2):672-681.
doi: 10.1002/jsfa.10063. Epub 2019 Nov 15.

Reversing UVB-induced photoaging with Hibiscus sabdariffa calyx aqueous extract

Jian Li  1 , Yi-Ru Lu  2 , I-Fan Lin  3 , Wenyi Kang  4 , Hong-Bin Chen  5 , Hsu-Feng Lu  6 , Hui-Min David Wang  1   5   7   8   9
Affiliations

Reversing UVB-induced photoaging with Hibiscus sabdariffa calyx aqueous extract

Jian Li et al. J Sci Food Agric. .

Abstract

Background: Hibiscus sabdariffa is commonly used in daily life and its extract is applied widely in food and cosmetics. However, it has not been evaluated for its anti-aging effects.

Results: Hibiscus sabdariffa calyx aqueous extract (HSCAE) has shown potential collagenase activity suppression effects, together with tyrosinase activity inhibition, and anti-oxidation as a free radical scavenger. The current investigation demonstrated that HSCAE was not cytotoxic in skin fibroblasts, and it significantly decreased ultraviolet B (UVB)-induced reactive oxygen species (ROS) on a flow cytometry assay. Moreover, HSCAE reduced matrix metalloproteinase (MMP) expression, increased tissue inhibition of metalloproteinase (TIMP)-1 level, and enhanced collagen content by inhibiting collagenase activity. It also blocked mRNA and protein expressions of melanin production pathway key factors, including the microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein-1 (TRP-1), and dopachrome tautomerase-2 (TRP-2).

Conclusion: These results demonstrated, for the first time, the potential of HSCAE as a natural antioxidant with the ability to maintain collagen production and to decrease melanin syntheses under UVB radiation, for anti-aging effects. © 2019 Society of Chemical Industry.

Keywords: Hibiscus sabdariffa; anti-aging; antioxidant; collagen; melanin.

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References

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