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. 2019 Oct;82(4):348-356.
doi: 10.4046/trd.2019.0016.

Long-Term Outcomes of Adult Lung Transplantation Recipients: A Single-Center Experience in South Korea

Kyung Wook Jo  1 , Sang Bum Hong  1 , Dong Kwan Kim  2 , Sung Ho Jung  2 , Hyeong Ryul Kim  2 , Se Hoon Choi  2 , Geun Dong Lee  2 , Sang Oh Lee  3 , Kyung Hyun Do  4 , Eun Jin Chae  4 , In Cheol Choi  5 , Dae Kee Choi  5 , In Ok Kim  6 , Seung Il Park  7 , Tae Sun Shim  8
Affiliations

Long-Term Outcomes of Adult Lung Transplantation Recipients: A Single-Center Experience in South Korea

Kyung Wook Jo et al. Tuberc Respir Dis (Seoul). 2019 Oct.

Abstract

Background: Recently, the number of lung transplants in South Korea has increased. However, the long-term outcome data is limited. In this study, we aimed to investigate the long-term outcomes of adult lung transplantation recipients.

Methods: Among the patients that underwent lung transplantation at a tertiary referral center in South Korea between 2008 and 2017, adults patient who underwent deceased-donor lung transplantation with available follow-up data were enrolled. Their medical records were retrospectively reviewed.

Results: Through eligibility screening, we identified 60 adult patients that underwent lung (n=51) or heart-lung transplantation (n=9) during the observation period. Idiopathic pulmonary fibrosis (46.7%, 28/60) was the most frequent cause of lung transplantation. For all the 60 patients, the median follow-up duration for post-transplantation was 2.6 years (range, 0.01-7.6). During the post-transplantation follow-up period, 19 patients (31.7%) died at a median duration of 194 days. The survival rates were 75.5%, 67.6%, and 61.8% at 1 year, 3 years, and 5 years, respectively. Out of the 60 patients, 8 (13.3%) were diagnosed with chronic lung allograft dysfunction (CLAD), after a mean duration of 3.3±2.8 years post-transplantation. The CLAD development rate was 0%, 17.7%, and 25.8% at 1 year, 3 years, and 5 years, respectively. The most common newly developed post-transplantation comorbidity was the chronic kidney disease (CKD; 54.0%), followed by diabetes mellitus (25.9%).

Conclusion: Among the adult lung transplantation recipients at a South Korea tertiary referral center, the long-term survival rates were favorable. The proportion of patients who developed CLAD was not substantial. CKD was the most common post-transplantation comorbidity.

Keywords: Chronic Kidney Disease; Chronic Lung Allograft Dysfunction; Lung Transplantation; Survival.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. Study flow chart. LDLLT: living-donor lobar lung transplantation.
Figure 2
Figure 2. Kaplan-Meier survival rates of 60 patients who underwent lung transplantation.
Figure 3
Figure 3. Kaplan-Meier estimates for chronic lung allograft dysfunction (CLAD) development of 60 patients who underwent lung transplantation.
See this image and copyright information in PMC

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