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. 2020 Jan 8;48(D1):D554-D560.
doi: 10.1093/nar/gkz843.

gutMDisorder: a comprehensive database for dysbiosis of the gut microbiota in disorders and interventions

Liang Cheng  1   2 , Changlu Qi  2 , He Zhuang  2 , Tongze Fu  2 , Xue Zhang  1   3
Affiliations

gutMDisorder: a comprehensive database for dysbiosis of the gut microbiota in disorders and interventions

Liang Cheng et al. Nucleic Acids Res. .

Erratum in

Abstract

gutMDisorder (http://bio-annotation.cn/gutMDisorder), a manually curated database, aims at providing a comprehensive resource of dysbiosis of the gut microbiota in disorders and interventions. Alterations in the composition of the gut microbial community play crucial roles in the development of chronic disorders. And the beneficial effects of drugs, foods and other intervention measures on disorders could be microbially mediated. The current version of gutMDisorder documents 2263 curated associations between 579 gut microbes and 123 disorders or 77 intervention measures in Human, and 930 curated associations between 273 gut microbes and 33 disorders or 151 intervention measures in Mouse. Each entry in the gutMDisorder contains detailed information on an association, including an intestinal microbe, a disorder name, intervention measures, experimental technology and platform, characteristic of samples, web sites for downloading the sequencing data, a brief description of the association, a literature reference, and so on. gutMDisorder provides a user-friendly interface to browse, retrieve each entry using gut microbes, disorders, and intervention measures. It also offers pages for downloading all the entries and submitting new experimentally validated associations.

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Figures

Figure 1.
Figure 1.
The process of data collection.
Figure 2.
Figure 2.
The distribution of gut microbes, disorders, and intervention measures in gutMDisorder. (A) The distribution of gut microbes in Human among different taxa. (B) The distribution of gut microbes in Mouse among different taxa. (C) Histogram of the number of microbes in Human associated with individual disease or intervention measure. (D) Histogram of the number of microbes in Mouse associated with individual disease or intervention measure. (E) Histogram of the number of diseases and intervention measures associated with individual microbe in Human. (F) Histogram of the number of diseases and intervention measures associated with individual microbe in Mouse.
Figure 3.
Figure 3.
Schematic workflow of gutMDisorder.
See this image and copyright information in PMC

References

    1. Gregory D., Chaudet H., Lagier J.C., Raoult D.. How mass spectrometric approaches applied to bacterial identification have revolutionized the study of human gut microbiota. Expert Review of Proteomics. 2018; 15:217–229. - PubMed
    1. Backhed F., Ley R.E., Sonnenburg J.L., Peterson D.A., Gordon J.I.. Host-bacterial mutualism in the human intestine. Science. 2005; 307:1915–1920. - PubMed
    1. Sender R., Fuchs S., Milo R.. Revised estimates for the number of human and bacteria cells in the body. PLoS Biol. 2016; 14:e1002533. - PMC - PubMed
    1. Gensollen T., Iyer S.S., Kasper D.L., Blumberg R.S.. How colonization by microbiota in early life shapes the immune system. Science. 2016; 352:539–544. - PMC - PubMed
    1. Lozupone C.A., Stombaugh J.I., Gordon J.I., Jansson J.K., Knight R.. Diversity, stability and resilience of the human gut microbiota. Nature. 2012; 489:220–230. - PMC - PubMed

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