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Review
. 2020 Mar 1;78(3):207-214.
doi: 10.1093/nutrit/nuz058.

Nutritional strategies to modulate inflammation pathways via regulation of peroxisome proliferator-activated receptor β/δ

Beatriz O da Cruz  1 , Ludmila F M de França Cardozo  1 , D'Angelo C Magliano  1   2 , Milena B Stockler-Pinto  1   3
Affiliations
Review

Nutritional strategies to modulate inflammation pathways via regulation of peroxisome proliferator-activated receptor β/δ

Beatriz O da Cruz et al. Nutr Rev. .

Abstract

The peroxisome proliferator-activated receptor (PPAR) β/δ has an important role in multiple inflammatory conditions, including obesity, hypertension, cancer, cardiovascular disease, diabetes mellitus, and autoimmune diseases. PPARβ/δ forms a heterodimer with the retinoic acid receptor and binds to peroxisome proliferator response elements to initiate transcription of its target genes. PPARβ/δ is also able to suppress the activities of several transcription factors, including nuclear factor κB, and activator protein 1, thus regulating anti-inflammatory cellular responses and playing a protective role in several diseases. Recent studies have shown that nutritional compounds, including nutrients and bioactive compounds, can regulate PPARβ/δ expression. This review discusses key nutritional compounds that are known to modulate PPARβ/δ and are likely to affect human health.

Keywords: PPAR beta; PPAR delta; inflammation; nutrients.

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