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. 2019 Oct 3;25(4):449-451.
doi: 10.1016/j.stem.2019.09.006.

Smelling Danger: Olfactory Stem Cells Control Immune Defense during Chronic Inflammation

Justin Rustenhoven  1 , Jonathan Kipnis  2
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Smelling Danger: Olfactory Stem Cells Control Immune Defense during Chronic Inflammation

Justin Rustenhoven et al. Cell Stem Cell. .
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Abstract

Neurogenesis is critical to continuously replacie olfactory neurons but is impaired during chronic inflammatory rhinosinusitis. In this issue of Cell Stem Cell, Chen et al. (2019) describe the inflammation-induced switching of olfactory stem cells from a regenerative phenotype to one participating in immune defense; this process contributes to deficient replacement of olfactory sensory neurons.

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