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. 2019 Oct 3;25(4):451-453.
doi: 10.1016/j.stem.2019.09.007.

Collisions on the Busy DNA Highway Set Up Barriers for Reprogramming

Xiao Hu  1 , Shangqin Guo  2
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Collisions on the Busy DNA Highway Set Up Barriers for Reprogramming

Xiao Hu et al. Cell Stem Cell. .
Free article

Abstract

Why most cells remain refractory to transcription factor (TF)-induced fate conversion remains largely mysterious, with the answers holding important instructions on how to effectively direct cell identities. In this issue of Cell Stem Cell, Babos et al. (2019) show that conflicts caused by simultaneous high transcription and high replication rates are to blame.

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