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Comment
. 2019 Oct 3;76(1):3-5.
doi: 10.1016/j.molcel.2019.08.027.

Going in Circles: The Black Box of Circular RNA Immunogenicity

Megha G Basavappa  1 , Sara Cherry  2
Affiliations
Free article
Comment

Going in Circles: The Black Box of Circular RNA Immunogenicity

Megha G Basavappa et al. Mol Cell. .
Free article

Abstract

Two recent papers in Molecular Cell (Chen et al., 2019; Wesselhoeft et al., 2019) have probed the putative immunogenicity of circular RNAs (circRNAs). These studies indicate that the stimulatory capacity of circRNAs depends on factors including the specific RNA, the mode of biogenesis, RNA modifications, cell type, and the means of delivery.

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  • N6-Methyladenosine Modification Controls Circular RNA Immunity.
    Chen YG, Chen R, Ahmad S, Verma R, Kasturi SP, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, Hur S, Chang HY. Chen YG, et al. Mol Cell. 2019 Oct 3;76(1):96-109.e9. doi: 10.1016/j.molcel.2019.07.016. Epub 2019 Aug 29. Mol Cell. 2019. PMID: 31474572 Free PMC article.

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