V1 microcircuits underlying mouse visual behavior

Abstract

Visual behavior is based on the concerted activity of neurons in visual areas, where sensory signals are integrated with top-down information. In the past decade, the advent of new tools, such as functional imaging of populations of identified single neurons, high-density electrophysiology, virus-assisted circuit mapping, and precisely timed, cell-type specific manipulations, has advanced our understanding of the neuronal microcircuits underlying visual behavior. Studies in head-fixed mice, where such tools can routinely be applied, begin to provide new insights into the neural code of primary visual cortex (V1) underlying visual perception, and the micro-circuits of attention, predictive processing, and learning.