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Case Reports
. 2019 Nov;31(6):879-882.
doi: 10.1177/1040638719879737. Epub 2019 Oct 4.

Inflammatory myofibroblastic tumor of the pancreas in a dog

Mariarita Romanucci  1 , Sabrina V P Defourny  1 , Marcella Massimini  1 , Laura Bongiovanni  1 , Giovanni Aste  1 , Massimo Vignoli  1 , Elettra Febo  1 , Andrea Boari  1 , Leonardo Della Salda  1
Affiliations
Case Reports

Inflammatory myofibroblastic tumor of the pancreas in a dog

Mariarita Romanucci et al. J Vet Diagn Invest. 2019 Nov.

Abstract

A large, ill-defined, firm, multinodular mass involving the pancreas was confirmed on postmortem examination of a 5-y-old, male Rottweiler that died following acute respiratory distress syndrome, after a period of anorexia and lethargy. Histologically, the mass consisted of plump spindle cells admixed with a variable number of macrophages, lymphocytes, plasma cells, and neutrophils. Foci of coagulative necrosis and hemorrhage were also observed. Spindle cells strongly reacted to antibodies against vimentin, α-smooth muscle actin, and calponin, whereas desmin was expressed only mildly and focally. Pan-cytokeratin, KIT, glial fibrillary acidic protein, and S100 protein were nonreactive. Variable numbers of MAC 387-positive cells, CD3+ lymphocytes, and numerous blood vessels were also detected throughout the mass. Histologic and IHC findings were consistent with a diagnosis of inflammatory myofibroblastic tumor of the pancreas.

Keywords: dogs; inflammatory myofibroblastic tumor; pancreas; pancreatitis.

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Conflict of interest statement

Declaration of conflicting interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figures 1–4.
Figures 1–4.
Inflammatory myofibroblastic tumor of the pancreas in a dog. Figure 1. Ultrasound image with a large, heterogeneous mass (arrows) involving the pancreas, with reduced detail of the surrounding mesenteric tissue. Figure 2. Large, ill-defined, multinodular mass involving the pancreatic body, with superficial fat necrosis (arrow) and variegated appearance as a result of necrotic areas. Figure 3. Haphazardly arranged plump spindle cells with admixed macrophages, lymphocytes, plasma cells, and neutrophils. H&E. Bar = 22 μm. Figure 4. Intense and diffuse labeling of spindle cells for α–smooth muscle actin. IHC. Bar = 45 μm. Inset: several von Willebrand factor–positive blood vessels admixed with negative spindle cells are visible. IHC. Bar = 60 μm.
See this image and copyright information in PMC

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