Should we continue to test soluble thrombomodulin, or other systemic anticoagulants, as a life-saving therapy for sepsis-induced coagulopathy?

Affiliations

¹ St. Luc Clinical Coordinating Center, Department of Critical Care Medicine, St Luc University Hospital, Université Catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address: pierre-francois.laterre@uclouvain.be.
² Ocean State Clinical Coordinating Center of Rhode Island Hospital, Providence, RI, USA.
³ St. Luc Clinical Coordinating Center, Department of Critical Care Medicine, St Luc University Hospital, Université Catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium.
⁴ St. Luc Clinical Coordinating Center, Department of Critical Care Medicine, St Luc University Hospital, Université Catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium; Department of Critical Care, Clinique St. Pierre, Ottignies, Belgium.
⁵ InsermCIC-1435 & UMR-1092, department of critical care, CHU Dupuytren, 87000, Limoges, France.

Editorial

Pierre-Francois Laterre et al. Anaesth Crit Care Pain Med. 2019 Oct.

. 2019 Oct;38(5):419-421.

doi: 10.1016/j.accpm.2019.09.003.

¹ St. Luc Clinical Coordinating Center, Department of Critical Care Medicine, St Luc University Hospital, Université Catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address: pierre-francois.laterre@uclouvain.be.
² Ocean State Clinical Coordinating Center of Rhode Island Hospital, Providence, RI, USA.
³ St. Luc Clinical Coordinating Center, Department of Critical Care Medicine, St Luc University Hospital, Université Catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium.
⁴ St. Luc Clinical Coordinating Center, Department of Critical Care Medicine, St Luc University Hospital, Université Catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium; Department of Critical Care, Clinique St. Pierre, Ottignies, Belgium.
⁵ InsermCIC-1435 & UMR-1092, department of critical care, CHU Dupuytren, 87000, Limoges, France.

No abstract available

Comment on

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.
Vincent JL, Francois B, Zabolotskikh I, Daga MK, Lascarrou JB, Kirov MY, Pettilä V, Wittebole X, Meziani F, Mercier E, Lobo SM, Barie PS, Crowther M, Esmon CT, Fareed J, Gando S, Gorelick KJ, Levi M, Mira JP, Opal SM, Parrillo J, Russell JA, Saito H, Tsuruta K, Sakai T, Fineberg D; SCARLET Trial Group. Vincent JL, et al. JAMA. 2019 May 28;321(20):1993-2002. doi: 10.1001/jama.2019.5358. JAMA. 2019. PMID: 31104069 Free PMC article. Clinical Trial.