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Comment
. 2019 Dec 1;25(23):6896-6898.
doi: 10.1158/1078-0432.CCR-19-2732. Epub 2019 Oct 4.

Class(y) Dissection of BRAF Heterogeneity: Beyond Non-V600

Elisa Fontana  1 , Nicola Valeri  2   3   4
Affiliations
Comment

Class(y) Dissection of BRAF Heterogeneity: Beyond Non-V600

Elisa Fontana et al. Clin Cancer Res. .

Abstract

Different classes of BRAF mutations are present in colorectal and other cancers. Non-V600 mutations are rare; however, their detection rate will increase as the use of next-generation sequencing ramps up quickly in clinical practice. Different biochemical signaling pathways are active in non-V600 BRAF-mutant cancers and may affect treatment response.See related article by Yaeger et al., p. 7089.

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