Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1985 May;84(5):410-2.
doi: 10.1111/1523-1747.ep12265510.

The composition of the ceramides from human stratum corneum and from comedones

P W Wertz, M C Miethke, S A Long, J S Strauss, D T Downing
Free article
Comparative Study

The composition of the ceramides from human stratum corneum and from comedones

P W Wertz et al. J Invest Dermatol. 1985 May.
Free article

Abstract

Human epidermal surface lipids were collected by an ethanol wash and the ceramides were quantified by thin-layer chromatography-photodensitometry. Six ceramide fractions were isolated and the structural components of each were analyzed in detail. The most unusual of the epidermal ceramides contained a sphingosine base with amide-linked 30- and 32-carbon omega-hydroxyacids and an ester-linked nonhydroxyacid, 41% of which was linoleic acid. The proportion of linoleic acid in the analogous ceramide from comedones was 6%. This supports the hypothesis that a localized insufficiency of linoleic acid in the follicular epithelium is an etiologic factor in comedogenesis.

PubMed Disclaimer

Publication types