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. 2019 Nov 26;520(1):225-230.
doi: 10.1016/j.bbrc.2019.10.001. Epub 2019 Oct 3.

The evaluation of Cannabidiol's effect on the immunotherapy of Burkitt lymphoma

Tomiteru Togano  1 , Naomi Kim  2 , Natalie Kim  2 , Gabriel S Park  3 , Alex K Park  2 , Maura Bennet  4 , Jino Park  5
Affiliations

The evaluation of Cannabidiol's effect on the immunotherapy of Burkitt lymphoma

Tomiteru Togano et al. Biochem Biophys Res Commun. .

Abstract

Aim: AF1q has a precise oncogenic function. The purpose of this study is to investigate whether CBD has an effect on the AF1q/ICAM-1 regulatory axis in Burkitt's lymphoma (BL), and thus has potential to enhance immunotherapy and reduce side effects.

Methods: We established BL cell lines with altered AF1q expression using lentivirus. After confirmation of gene expression by RT-PCR, cells were treated with CBD followed by co-culture of killing assay.

Results: AF1q increased oncogenic growth and colony formation, and induced resistance against cell-mediated cytotoxic chemotherapy through attenuation of ICAM-1 expression in BL. CBD was able to reverse the acquired resistance mediated by AF1q/ICAM-1 regulatory axis.

Conclusion: CBD holds potential to enhance the efficacy of immunotherapy for BL with hyperactive AF1q/ICAM-1 regulatory axis, and warrants further study.

Keywords: AF1q; BL; Burkitt lymphoma; CBD; Cannabidiol; ICAM-1; Immunotherapy.

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