Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults

doi:10.1016/j.jalz.2019.07.013

. 2019 Dec;15(12):1603-1611.

doi: 10.1016/j.jalz.2019.07.013. Epub 2019 Oct 3.

Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults

Erika Ogino¹, Jennifer J Manly², Nicole Schupf³, Richard Mayeux⁴, Yian Gu⁵

Affiliations

¹ Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
² Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
³ Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA.
⁴ Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA.
⁵ Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address: yg2121@cumc.columbia.edu.

PMID: 31587996
PMCID: PMC6948182
DOI: 10.1016/j.jalz.2019.07.013

Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults

Erika Ogino et al. Alzheimers Dement. 2019 Dec.

. 2019 Dec;15(12):1603-1611.

doi: 10.1016/j.jalz.2019.07.013. Epub 2019 Oct 3.

Authors

Erika Ogino¹, Jennifer J Manly², Nicole Schupf³, Richard Mayeux⁴, Yian Gu⁵

Affiliations

¹ Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
² Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
³ Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA.
⁴ Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA.
⁵ Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address: yg2121@cumc.columbia.edu.

PMID: 31587996
PMCID: PMC6948182
DOI: 10.1016/j.jalz.2019.07.013

Abstract

Introduction: The associations between self-reported current and past leisure time physical activity (LTPA) and Alzheimer's disease (AD) incidence were determined using data from the multiethnic Washington/Hamilton Heights-Inwood Columbia Aging Project (WHICAP) study.

Methods: The metabolic equivalent of LTPA energy expenditure was calculated for self-reported current and past LTPA for 1345 older adults. A Cox proportional hazard model was conducted to estimate the association between LTPA (low, middle, and high) and incident AD risk.

Results: Comparing high to low level, current and past LTPA were both associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.39 (0.20-0.75) and 0.37 (0.18-0.75), respectively. Compared with "always low," "increased" and "always high" LTPA throughout life were associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.60 (0.36-0.99) and 0.28 (0.08-0.94), respectively. Light- and moderate-intensity LTPA were associated with lower AD risk.

Discussion: LTPA both throughout life and later in life are associated with lower risk of AD.

Keywords: Alzheimer's disease; Dementia; Epidemiology; Longitudinal study; Physical activity.

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References

1. World Alzheimer Report. Alzheimer’s Disease International; 2016.
1. Fabrigoule C, Letenneur L, Dartigues JF, Zarrouk M, Commenges D, Barberger-Gateau P. Social and leisure activities and risk of dementia: a prospective longitudinal study. J Am Geriatr Soc. 1995;43(5):485–90. - PubMed
1. Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Archives of neurology. 2001;58(3):498–504. - PubMed
1. Podewils LJ, Guallar E, Kuller LH, Fried LP, Lopez OL, Carlson M, et al. Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. American journal of epidemiology. 2005;161(7):639–51. - PubMed
1. Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P, et al. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Annals of internal medicine. 2006;144(2):73–81. - PubMed

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[1] World Alzheimer Report. Alzheimer’s Disease International; 2016.

[2] World Alzheimer Report. Alzheimer’s Disease International; 2016.

[3] Fabrigoule C, Letenneur L, Dartigues JF, Zarrouk M, Commenges D, Barberger-Gateau P. Social and leisure activities and risk of dementia: a prospective longitudinal study. J Am Geriatr Soc. 1995;43(5):485–90. - PubMed

[4] Fabrigoule C, Letenneur L, Dartigues JF, Zarrouk M, Commenges D, Barberger-Gateau P. Social and leisure activities and risk of dementia: a prospective longitudinal study. J Am Geriatr Soc. 1995;43(5):485–90. - PubMed

[5] Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Archives of neurology. 2001;58(3):498–504. - PubMed

[6] Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Archives of neurology. 2001;58(3):498–504. - PubMed

[7] Podewils LJ, Guallar E, Kuller LH, Fried LP, Lopez OL, Carlson M, et al. Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. American journal of epidemiology. 2005;161(7):639–51. - PubMed

[8] Podewils LJ, Guallar E, Kuller LH, Fried LP, Lopez OL, Carlson M, et al. Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. American journal of epidemiology. 2005;161(7):639–51. - PubMed

[9] Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P, et al. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Annals of internal medicine. 2006;144(2):73–81. - PubMed

[10] Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P, et al. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Annals of internal medicine. 2006;144(2):73–81. - PubMed

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Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults

Affiliations

Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults

Authors

Affiliations

Abstract

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