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Case Reports
. 2020 Apr 30;9(2):277-280.
doi: 10.1093/jpids/piz055.

Congenital Leishmaniasis in a Newborn Infant Whose Mother was Coinfected With Leishmaniasis and HIV

Nicolas Argy  1   2   3 , Sylvie Lariven  4 , Aline Rideau  5 , Anais Lemoine  6 , Agnès Bourgeois Moine  7 , Lahcene Allal  7 , Laurence Choudat  8 , Christophe Ravel  9 , Florence Michard  4 , Pierre Buffet  10 , Albert Faye  11   12   13 , Sandrine Houze  1   2   3 , Yazdan Yazdanpanah  4   12   14
Affiliations
Case Reports

Congenital Leishmaniasis in a Newborn Infant Whose Mother was Coinfected With Leishmaniasis and HIV

Nicolas Argy et al. J Pediatric Infect Dis Soc. .

Abstract

In utero transmission of Leishmania infantum is the putative mechanism of congenital leishmaniasis. However, this hypothesis is based on limited research. In addition, the consequences for infant newborn development remain to be clarified by additional data. We report here the occurrence, specific management, and monitoring of congenital leishmaniasis in a newborn infant whose mother was coinfected with leishmaniasis and human immunodeficiency virus; transplacental transmission, confirmed by overt clinical disease at birth, was documented, which provides, to our knowledge, the first evidence of hepatic and neurologic impairment in an infant with congenital visceral leishmaniasis.

Keywords: Leishmania–HIV coinfection; amphotericin B failure; congenital; leishmaniasis; transplacental.

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