2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk

doi:10.1016/j.atherosclerosis.2019.08.014

Review

. 2019 Nov:290:140-205.

doi: 10.1016/j.atherosclerosis.2019.08.014. Epub 2019 Aug 31.

2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk

Authors/Task Force Members; ESC Committee for Practice Guidelines (CPG); ESC National Cardiac Societies

Collaborators, Affiliations

Collaborators

François Mach¹, Colin Baigent², Alberico L Catapano³, Konstantinos C Koskinas⁴, Manuela Casula⁵, Lina Badimon⁶, M John Chapman⁷, Guy G De Backer⁸, Victoria Delgado⁹, Brian A Ference¹⁰, Ian M Graham¹¹, Alison Halliday¹², Ulf Landmesser¹³, Borislava Mihaylova¹⁴, Terje R Pedersen¹⁵, Gabriele Riccardi¹⁶, Dimitrios J Richter¹⁷, Marc S Sabatine¹⁸, Marja-Riitta Taskinen¹⁹, Lale Tokgozoglu²⁰, Olov Wiklund²¹, Stephan Windecker²², Victor Aboyans²³, Colin Baigent²⁴, Jean-Philippe Collet²³, Veronica Dean²³, Victoria Delgado²⁵, Donna Fitzsimons²⁴, Chris P Gale²⁴, Diederick Grobbee²⁵, Sigrun Halvorsen²⁶, Gerhard Hindricks²⁷, Bernard Iung²³, Peter Jüni²⁸, Hugo A Katus²⁷, Ulf Landmesser²⁷, Christophe Leclercq²³, Maddalena Lettino²⁹, Basil S Lewis³⁰, Bela Merkely³¹, Christian Mueller²², Steffen Petersen²⁴, Anna Sonia Petronio²⁹, Dimitrios J Richter³², Marco Roffi²², Evgeny Shlyakhto³³, Iain A Simpson²⁴, Miguel Sousa-Uva³⁴, Rhian M Touyz²⁴, Djamaleddine Nibouche³⁵, Parounak H Zelveian³⁶, Peter Siostrzonek³⁷, Ruslan Najafov³⁸, Philippe van de Borne³⁹, Belma Pojskic⁴⁰, Arman Postadzhiyan⁴¹, Lambros Kypris⁴², Jindřich Špinar⁴³, Mogens Lytken Larsen⁴⁴, Hesham Salah Eldin⁴⁵, Margus Viigimaa⁴⁶, Timo E Strandberg⁴⁷, Jean Ferrières⁴⁸, Rusudan Agladze⁴⁹, Ulrich Laufs⁵⁰, Loukianos Rallidis⁵¹, László Bajnok⁵², Thorbjörn Gudjónsson⁵³, Vincent Maher⁵⁴, Yaakov Henkin⁵⁵, Michele Massimo Gulizia⁵⁶, Aisulu Mussagaliyeva⁵⁷, Gani Bajraktari⁵⁸, Alina Kerimkulova⁵⁹, Gustavs Latkovskis⁶⁰, Omar Hamoui⁶¹, Rimvydas Slapikas⁶², Laurent Visser⁶³, Philip Dingli⁶⁴, Victoria Ivanov⁶⁵, Aneta Boskovic⁶⁶, Mbarek Nazzi⁶⁷, Frank Visseren⁶⁸, Irena Mitevska⁶⁹, Kjetil Retterstøl⁷⁰, Piotr Jankowski⁷¹, Ricardo Fontes-Carvalho⁷², Dan Gaita⁷³, Marat Ezhov⁷⁴, Marina Foscoli⁷⁵, Vojislav Giga⁷⁶, Daniel Pella⁷⁷, Zlatko Fras⁷⁸, Leopoldo Perez de Isla⁷⁹, Emil Hagström⁸⁰, Roger Lehmann⁸¹, Leila Abid⁸², Oner Ozdogan⁸³, Olena Mitchenko⁸⁴, Riyaz S Patel⁸⁵

Affiliations

¹ Cardiology Department, Geneva University Hospital, 4 Gabrielle-Perret-Gentil, 1211, Geneva, Switzerland. Electronic address: francois.mach@hcuge.ch.
² Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, United Kingdom. Electronic address: colin.baigent@ndph.ox.ac.uk.
³ Department of Pharmacological and Biomolecular Sciences, University of Milan, Multimedica IRCCS, Via Balzaretti, 9, 20133, Milan, Italy. Electronic address: alberico.catapano@unimi.it.
⁴ Cardiology, Bern University Hospital (Inselspital), Bern, Switzerland.
⁵ Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, Milan, Italy; IRCCS MultiMedica, Sesto S. Giovanni, Milan, Italy.
⁶ Cardiovascular Program-ICCC and CiberCV, IR-Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
⁷ National Institute for Health and Medical Research (INSERM), Paris, France; Division of Endocrinology- Metabolism, Pitie-Salpetriere University Hospital, Paris, France; Sorbonne University, Paris, France.
⁸ Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
⁹ Cardiology, Leiden University Medical Center, Leiden, Netherlands.
¹⁰ Centre for Naturally Randomized Trials, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
¹¹ Cardiology, Trinity College, Dublin, Ireland.
¹² Nuffield Department of Surgery, University of Oxford, NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
¹³ Department of Cardiology, Charite Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany; German Center of Cardiovascular Research (DZHK), Berlin, Germany.
¹⁴ Nuffield Department of Population Health, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
¹⁵ Preventive Cardiology, Oslo University Hospital, Aker, Oslo, Norway.
¹⁶ Clinical Medicine and Surgery, Federico II University, Naples, Italy.
¹⁷ Cardiac Department, Euroclinic, Athens, Greece.
¹⁸ TIMI Study Group, Division of Cardiovascular Medicine, Brigham, Women's Hospital and Harvard Medical School, Boston, MA, United States of America.
¹⁹ Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.
²⁰ Cardiology, Hacettepe University, Ankara, Turkey.
²¹ Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
²² Switzerland.
²³ France.
²⁴ United Kingdom.
²⁵ Netherlands.
²⁶ Norway.
²⁷ Germany.
²⁸ Canada.
²⁹ Italy.
³⁰ Israel.
³¹ Hungary.
³² Greece.
³³ Russian Federation.
³⁴ Portugal.
³⁵ Algerian Society of Cardiology, Algeria.
³⁶ Armenian Cardiologists Association, Armenia.
³⁷ Austrian Society of Cardiology, Austria.
³⁸ Azerbaijan Society of Cardiology, Azerbaijan.
³⁹ Belgian Society of Cardiology, Belgium.
⁴⁰ Association of Cardiologists of Bosnia and Herzegovina, Bosnia and Herzegovina.
⁴¹ Bulgarian Society of Cardiology, Bulgaria.
⁴² Cyprus Society of Cardiology, Cyprus.
⁴³ Czech Society of Cardiology, Czech Republic.
⁴⁴ Danish Society of Cardiology, Denmark.
⁴⁵ Egyptian Society of Cardiology, Egypt.
⁴⁶ Estonian Society of Cardiology, Estonia.
⁴⁷ Finnish Cardiac Society, Finland.
⁴⁸ French Society of Cardiology, France.
⁴⁹ Georgian Society of Cardiology, Georgia.
⁵⁰ German Cardiac Society, Germany.
⁵¹ Hellenic Society of Cardiology, Greece.
⁵² Hungarian Society of Cardiology, Hungary.
⁵³ Icelandic Society of Cardiology, Iceland.
⁵⁴ Irish Cardiac Society, Ireland.
⁵⁵ Israel Heart Society, Israel.
⁵⁶ Italian Federation of Cardiology, Italy.
⁵⁷ Association of Cardiologists of Kazakhstan, Kazakhstan.
⁵⁸ Kosovo Society of Cardiology, Republic of Kosovo.
⁵⁹ Kyrgyz Society of Cardiology, Kyrgyzstan.
⁶⁰ Latvian Society of Cardiology, Latvia.
⁶¹ Lebanese Society of Cardiology, Lebanon.
⁶² Lithuanian Society of Cardiology, Lithuania.
⁶³ Luxembourg Society of Cardiology, Luxembourg.
⁶⁴ Maltese Cardiac Society, Malta.
⁶⁵ Moldavian Society of Cardiology, Republic of Moldova.
⁶⁶ Montenegro Society of Cardiology, Montenegro.
⁶⁷ Moroccan Society of Cardiology, Morocco.
⁶⁸ Netherlands Society of Cardiology, Netherlands.
⁶⁹ North Macedonian Society of Cardiology, North Macedonia.
⁷⁰ Norwegian Society of Cardiology, Norway.
⁷¹ Polish Cardiac Society, Poland.
⁷² Portuguese Society of Cardiology, Portugal.
⁷³ Romanian Society of Cardiology, Romania.
⁷⁴ Russian Society of Cardiology, Russian Federation.
⁷⁵ San Marino Society of Cardiology, San Marino.
⁷⁶ Cardiology Society of Serbia, Serbia.
⁷⁷ Slovak Society of Cardiology, Slovakia.
⁷⁸ Slovenian Society of Cardiology, Slovenia.
⁷⁹ Spanish Society of Cardiology, Spain.
⁸⁰ Swedish Society of Cardiology, Sweden.
⁸¹ Swiss Society of Cardiology, Switzerland.
⁸² Tunisian Society of Cardiology and Cardio-Vascular Surgery, Tunisia.
⁸³ Turkish Society of Cardiology, Turkey.
⁸⁴ Ukrainian Association of Cardiology, Ukraine.
⁸⁵ British Cardiovascular Society, United Kingdom of Great Britain and Northern Ireland.

PMID: 31591002
DOI: 10.1016/j.atherosclerosis.2019.08.014

Free article

Review

2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk

Authors/Task Force Members et al. Atherosclerosis. 2019 Nov.

Free article

. 2019 Nov:290:140-205.

doi: 10.1016/j.atherosclerosis.2019.08.014. Epub 2019 Aug 31.

Authors

Authors/Task Force Members; ESC Committee for Practice Guidelines (CPG); ESC National Cardiac Societies

Collaborators

François Mach¹, Colin Baigent², Alberico L Catapano³, Konstantinos C Koskinas⁴, Manuela Casula⁵, Lina Badimon⁶, M John Chapman⁷, Guy G De Backer⁸, Victoria Delgado⁹, Brian A Ference¹⁰, Ian M Graham¹¹, Alison Halliday¹², Ulf Landmesser¹³, Borislava Mihaylova¹⁴, Terje R Pedersen¹⁵, Gabriele Riccardi¹⁶, Dimitrios J Richter¹⁷, Marc S Sabatine¹⁸, Marja-Riitta Taskinen¹⁹, Lale Tokgozoglu²⁰, Olov Wiklund²¹, Stephan Windecker²², Victor Aboyans²³, Colin Baigent²⁴, Jean-Philippe Collet²³, Veronica Dean²³, Victoria Delgado²⁵, Donna Fitzsimons²⁴, Chris P Gale²⁴, Diederick Grobbee²⁵, Sigrun Halvorsen²⁶, Gerhard Hindricks²⁷, Bernard Iung²³, Peter Jüni²⁸, Hugo A Katus²⁷, Ulf Landmesser²⁷, Christophe Leclercq²³, Maddalena Lettino²⁹, Basil S Lewis³⁰, Bela Merkely³¹, Christian Mueller²², Steffen Petersen²⁴, Anna Sonia Petronio²⁹, Dimitrios J Richter³², Marco Roffi²², Evgeny Shlyakhto³³, Iain A Simpson²⁴, Miguel Sousa-Uva³⁴, Rhian M Touyz²⁴, Djamaleddine Nibouche³⁵, Parounak H Zelveian³⁶, Peter Siostrzonek³⁷, Ruslan Najafov³⁸, Philippe van de Borne³⁹, Belma Pojskic⁴⁰, Arman Postadzhiyan⁴¹, Lambros Kypris⁴², Jindřich Špinar⁴³, Mogens Lytken Larsen⁴⁴, Hesham Salah Eldin⁴⁵, Margus Viigimaa⁴⁶, Timo E Strandberg⁴⁷, Jean Ferrières⁴⁸, Rusudan Agladze⁴⁹, Ulrich Laufs⁵⁰, Loukianos Rallidis⁵¹, László Bajnok⁵², Thorbjörn Gudjónsson⁵³, Vincent Maher⁵⁴, Yaakov Henkin⁵⁵, Michele Massimo Gulizia⁵⁶, Aisulu Mussagaliyeva⁵⁷, Gani Bajraktari⁵⁸, Alina Kerimkulova⁵⁹, Gustavs Latkovskis⁶⁰, Omar Hamoui⁶¹, Rimvydas Slapikas⁶², Laurent Visser⁶³, Philip Dingli⁶⁴, Victoria Ivanov⁶⁵, Aneta Boskovic⁶⁶, Mbarek Nazzi⁶⁷, Frank Visseren⁶⁸, Irena Mitevska⁶⁹, Kjetil Retterstøl⁷⁰, Piotr Jankowski⁷¹, Ricardo Fontes-Carvalho⁷², Dan Gaita⁷³, Marat Ezhov⁷⁴, Marina Foscoli⁷⁵, Vojislav Giga⁷⁶, Daniel Pella⁷⁷, Zlatko Fras⁷⁸, Leopoldo Perez de Isla⁷⁹, Emil Hagström⁸⁰, Roger Lehmann⁸¹, Leila Abid⁸², Oner Ozdogan⁸³, Olena Mitchenko⁸⁴, Riyaz S Patel⁸⁵

Affiliations

¹ Cardiology Department, Geneva University Hospital, 4 Gabrielle-Perret-Gentil, 1211, Geneva, Switzerland. Electronic address: francois.mach@hcuge.ch.
² Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, United Kingdom. Electronic address: colin.baigent@ndph.ox.ac.uk.
³ Department of Pharmacological and Biomolecular Sciences, University of Milan, Multimedica IRCCS, Via Balzaretti, 9, 20133, Milan, Italy. Electronic address: alberico.catapano@unimi.it.
⁴ Cardiology, Bern University Hospital (Inselspital), Bern, Switzerland.
⁵ Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, Milan, Italy; IRCCS MultiMedica, Sesto S. Giovanni, Milan, Italy.
⁶ Cardiovascular Program-ICCC and CiberCV, IR-Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
⁷ National Institute for Health and Medical Research (INSERM), Paris, France; Division of Endocrinology- Metabolism, Pitie-Salpetriere University Hospital, Paris, France; Sorbonne University, Paris, France.
⁸ Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
⁹ Cardiology, Leiden University Medical Center, Leiden, Netherlands.
¹⁰ Centre for Naturally Randomized Trials, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
¹¹ Cardiology, Trinity College, Dublin, Ireland.
¹² Nuffield Department of Surgery, University of Oxford, NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
¹³ Department of Cardiology, Charite Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany; German Center of Cardiovascular Research (DZHK), Berlin, Germany.
¹⁴ Nuffield Department of Population Health, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
¹⁵ Preventive Cardiology, Oslo University Hospital, Aker, Oslo, Norway.
¹⁶ Clinical Medicine and Surgery, Federico II University, Naples, Italy.
¹⁷ Cardiac Department, Euroclinic, Athens, Greece.
¹⁸ TIMI Study Group, Division of Cardiovascular Medicine, Brigham, Women's Hospital and Harvard Medical School, Boston, MA, United States of America.
¹⁹ Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.
²⁰ Cardiology, Hacettepe University, Ankara, Turkey.
²¹ Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
²² Switzerland.
²³ France.
²⁴ United Kingdom.
²⁵ Netherlands.
²⁶ Norway.
²⁷ Germany.
²⁸ Canada.
²⁹ Italy.
³⁰ Israel.
³¹ Hungary.
³² Greece.
³³ Russian Federation.
³⁴ Portugal.
³⁵ Algerian Society of Cardiology, Algeria.
³⁶ Armenian Cardiologists Association, Armenia.
³⁷ Austrian Society of Cardiology, Austria.
³⁸ Azerbaijan Society of Cardiology, Azerbaijan.
³⁹ Belgian Society of Cardiology, Belgium.
⁴⁰ Association of Cardiologists of Bosnia and Herzegovina, Bosnia and Herzegovina.
⁴¹ Bulgarian Society of Cardiology, Bulgaria.
⁴² Cyprus Society of Cardiology, Cyprus.
⁴³ Czech Society of Cardiology, Czech Republic.
⁴⁴ Danish Society of Cardiology, Denmark.
⁴⁵ Egyptian Society of Cardiology, Egypt.
⁴⁶ Estonian Society of Cardiology, Estonia.
⁴⁷ Finnish Cardiac Society, Finland.
⁴⁸ French Society of Cardiology, France.
⁴⁹ Georgian Society of Cardiology, Georgia.
⁵⁰ German Cardiac Society, Germany.
⁵¹ Hellenic Society of Cardiology, Greece.
⁵² Hungarian Society of Cardiology, Hungary.
⁵³ Icelandic Society of Cardiology, Iceland.
⁵⁴ Irish Cardiac Society, Ireland.
⁵⁵ Israel Heart Society, Israel.
⁵⁶ Italian Federation of Cardiology, Italy.
⁵⁷ Association of Cardiologists of Kazakhstan, Kazakhstan.
⁵⁸ Kosovo Society of Cardiology, Republic of Kosovo.
⁵⁹ Kyrgyz Society of Cardiology, Kyrgyzstan.
⁶⁰ Latvian Society of Cardiology, Latvia.
⁶¹ Lebanese Society of Cardiology, Lebanon.
⁶² Lithuanian Society of Cardiology, Lithuania.
⁶³ Luxembourg Society of Cardiology, Luxembourg.
⁶⁴ Maltese Cardiac Society, Malta.
⁶⁵ Moldavian Society of Cardiology, Republic of Moldova.
⁶⁶ Montenegro Society of Cardiology, Montenegro.
⁶⁷ Moroccan Society of Cardiology, Morocco.
⁶⁸ Netherlands Society of Cardiology, Netherlands.
⁶⁹ North Macedonian Society of Cardiology, North Macedonia.
⁷⁰ Norwegian Society of Cardiology, Norway.
⁷¹ Polish Cardiac Society, Poland.
⁷² Portuguese Society of Cardiology, Portugal.
⁷³ Romanian Society of Cardiology, Romania.
⁷⁴ Russian Society of Cardiology, Russian Federation.
⁷⁵ San Marino Society of Cardiology, San Marino.
⁷⁶ Cardiology Society of Serbia, Serbia.
⁷⁷ Slovak Society of Cardiology, Slovakia.
⁷⁸ Slovenian Society of Cardiology, Slovenia.
⁷⁹ Spanish Society of Cardiology, Spain.
⁸⁰ Swedish Society of Cardiology, Sweden.
⁸¹ Swiss Society of Cardiology, Switzerland.
⁸² Tunisian Society of Cardiology and Cardio-Vascular Surgery, Tunisia.
⁸³ Turkish Society of Cardiology, Turkey.
⁸⁴ Ukrainian Association of Cardiology, Ukraine.
⁸⁵ British Cardiovascular Society, United Kingdom of Great Britain and Northern Ireland.

PMID: 31591002
DOI: 10.1016/j.atherosclerosis.2019.08.014

Erratum in

Erratum to "2019 ESC/EAS guidelines for the management of dyslipidemias: Lipid modification to reduce cardiovascular risk" [Atherosclerosis 290 (2019) 140-205].
Authors/Task Force Members; ESC National Cardiac Societies; ESC Committee for Practice Guidelines (CPG). Authors/Task Force Members, et al. Atherosclerosis. 2020 Jan;292:160-162. doi: 10.1016/j.atherosclerosis.2019.11.020. Epub 2019 Dec 4. Atherosclerosis. 2020. PMID: 31811963 No abstract available.
Corrigendum to "2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk" [Atherosclerosis 290 (2019) 140-205].
Task Force Members; ESC National Cardiac Societies; ESC Committee for Practice Guidelines (CPG). Task Force Members, et al. Atherosclerosis. 2020 Feb;294:80-82. doi: 10.1016/j.atherosclerosis.2019.12.004. Epub 2019 Dec 20. Atherosclerosis. 2020. PMID: 31870624 No abstract available.

No abstract available

Keywords: Apolipoprotein B; Cholesterol;; Dyslipidaemias; Familial hypercholesterolaemia; Guidelines; High-density lipoproteins; Lipoprotein remnants; Lipoprotein(a); Low-density lipoproteins; Total cardiovascular risk; Treatment (adherence); Treatment (drugs); Treatment (lifestyle); Triglycerides; Very low-density lipoproteins.

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Comment in

The changing landscape of lipid-lowering therapy after the new ESC/EAS guidelines for the management of dyslipidaemias: Launching the era of triple hypolipidaemic therapy in very high risk patients.
Rallidis LS. Rallidis LS. Atherosclerosis. 2020 Jan;292:231-233. doi: 10.1016/j.atherosclerosis.2019.11.009. Epub 2019 Nov 14. Atherosclerosis. 2020. PMID: 31784033 No abstract available.
Updated treatment thresholds in the 2019 ESC/EAS dyslipidaemia guidelines substantially expand indications for statin use for primary prevention at population level: Results from the Rotterdam Study.
Pavlović J, Kavousi M, Ikram MA, Leening MJG. Pavlović J, et al. Atherosclerosis. 2020 Apr;299:64-66. doi: 10.1016/j.atherosclerosis.2020.02.020. Epub 2020 Feb 29. Atherosclerosis. 2020. PMID: 32169303 No abstract available.
Very high-risk familial hypercholesterolaemia patients in real life: The remaining gap in achieving the current LDL-C targets despite the use of PCSK9 inhibitors.
Rallidis LS, Liberopoulos EN, Vlachopoulos C, Skoumas I, Kolovou G, Anastasiou G, Dima I, Tousoulis D, Iliodromitis E. Rallidis LS, et al. Atherosclerosis. 2020 Sep;309:67-69. doi: 10.1016/j.atherosclerosis.2020.07.018. Epub 2020 Jul 30. Atherosclerosis. 2020. PMID: 32859385 No abstract available.

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2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk

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2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk

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