Review

. 2019 Oct 7;20(19):4945.

doi: 10.3390/ijms20194945.

Sirtuins and SIRT6 in Carcinogenesis and in Diet

Maria de Céu Teixeira¹, Elena Sanchez-Lopez^{2

3

4}, Marta Espina^{5

6}, Maria Luisa Garcia^{7

8

9}, Alessandra Durazzo¹⁰, Massimo Lucarini¹¹, Ettore Novellino¹², Selma B Souto¹³, Antonello Santini¹⁴, Eliana B Souto^{15

16}

Affiliations

¹ Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. mceuteixeira1@gmail.com.
² Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain. esanchezlopez@ub.edu.
³ Institute of Nanoscience and nanotechnology (IN2UB), Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain. esanchezlopez@ub.edu.
⁴ CIBERNED Centros de Biomedicina en Red de Enfermedades Neurodegenerativas, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain. esanchezlopez@ub.edu.
⁵ Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain. m.espina@ub.edu.
⁶ Institute of Nanoscience and nanotechnology (IN2UB), Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain. m.espina@ub.edu.
⁷ Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain. marisagarcia@ub.edu.
⁸ Institute of Nanoscience and nanotechnology (IN2UB), Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain. marisagarcia@ub.edu.
⁹ CIBERNED Centros de Biomedicina en Red de Enfermedades Neurodegenerativas, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain. marisagarcia@ub.edu.
¹⁰ CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy. alessandra.durazzo@crea.gov.it.
¹¹ CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy. massimo.lucarini@crea.gov.it.
¹² Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy. ettore.novellino@unina.it.
¹³ Department of Endocrinology of Hospital de São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. sbsouto.md@gmail.com.
¹⁴ Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy. asantini@unina.it.
¹⁵ Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. ebsouto@ff.uc.pt.
¹⁶ CEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. ebsouto@ff.uc.pt.

PMID: 31591350
PMCID: PMC6801518
DOI: 10.3390/ijms20194945

Review

Sirtuins and SIRT6 in Carcinogenesis and in Diet

Maria de Céu Teixeira et al. Int J Mol Sci. 2019.

. 2019 Oct 7;20(19):4945.

doi: 10.3390/ijms20194945.

Authors

Affiliations

¹ Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. mceuteixeira1@gmail.com.
² Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain. esanchezlopez@ub.edu.
³ Institute of Nanoscience and nanotechnology (IN2UB), Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain. esanchezlopez@ub.edu.
⁴ CIBERNED Centros de Biomedicina en Red de Enfermedades Neurodegenerativas, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain. esanchezlopez@ub.edu.
⁵ Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain. m.espina@ub.edu.
⁶ Institute of Nanoscience and nanotechnology (IN2UB), Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain. m.espina@ub.edu.
⁷ Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain. marisagarcia@ub.edu.
⁸ Institute of Nanoscience and nanotechnology (IN2UB), Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain. marisagarcia@ub.edu.
⁹ CIBERNED Centros de Biomedicina en Red de Enfermedades Neurodegenerativas, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain. marisagarcia@ub.edu.
¹⁰ CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy. alessandra.durazzo@crea.gov.it.
¹¹ CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy. massimo.lucarini@crea.gov.it.
¹² Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy. ettore.novellino@unina.it.
¹³ Department of Endocrinology of Hospital de São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. sbsouto.md@gmail.com.
¹⁴ Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy. asantini@unina.it.
¹⁵ Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. ebsouto@ff.uc.pt.
¹⁶ CEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. ebsouto@ff.uc.pt.

PMID: 31591350
PMCID: PMC6801518
DOI: 10.3390/ijms20194945

Abstract

Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine modifying enzymes. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development and aging. Aging is one of the major risk factors of cancer, as many of the physiological mechanisms and pathologies associated with the aging process also contribute to tumor initiation, growth and/or metastasis. This review focuses on one the mammalian sirtuins, SIRT6, which has emerged as an important regulator of longevity and appears to have multiple biochemical functions that interfere with tumor development and may be useful in cancer prevention and for site-specific treatment. The recent evidence of the role of SIRT6 in carcinogenesis is also discussed, focusing on the potential use of SIRT6 modulators in cancer nanomedicine.

Keywords: SIRT6; cancer; chemotherapy; diet; modulator; sirtuins.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
SIRT 6 activities and functions. SIRT6 described activities, substrates and responses related to the aging process.

See this image and copyright information in PMC

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References

1. Voelter-Mahlknecht S., Mahlknecht U. The sirtuins in the pathogenesis of cancer. Clinic. Epigen. 2010;1:71–83. doi: 10.1007/s13148-010-0008-0. - DOI - PMC - PubMed
1. Warburg O. On the origin of cancer cells. Science. 1956;123:309–314. doi: 10.1126/science.123.3191.309. - DOI - PubMed
1. Wise D.R., Thompson C.B. Glutamine addiction: A new therapeutic target in cancer. Trends Biochem. Sci. 2010;35:427–433. doi: 10.1016/j.tibs.2010.05.003. - DOI - PMC - PubMed
1. Santos C.R., Schulze A. Lipid metabolism in cancer. FEBS J. 2012;279:2610–2623. doi: 10.1111/j.1742-4658.2012.08644.x. - DOI - PubMed
1. Cosentino C., Grieco D., Costanzo V. ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J. 2011;30:546–555. doi: 10.1038/emboj.2010.330. - DOI - PMC - PubMed

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Sirtuins and SIRT6 in Carcinogenesis and in Diet

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Sirtuins and SIRT6 in Carcinogenesis and in Diet

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