Bone marrow blast elimination by the fifth day of 7 + 3 induction is the strongest predictor of potential cure in patients with acute myeloid leukemia younger than 61 years of age: A long-term follow-up of a multi-center prospective study

Yishai Ofran^{1

2}, Michal Hayun¹, Ronit Leiba³, Tsila Zuckerman^{1

2}, Netanel Horowitz^{1

2}, Ron Hoffman^{1

2}, Shimrit Ringelstein¹, Noa Lavi^{1

2}, Avraham Frisch¹, Israel Henig¹, Moshe E Gatt⁴, Ilana Hellmann⁵, Ariela Arad⁴, Shlomo Bulvik⁶, Ron Ram⁷, Sharon Gino-Moor⁸, Revital Saban⁴, Ariella Tvito⁹, Jacob M Rowe^{1

2

9}, Chezi Ganzel⁹

Affiliations

¹ Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel.
² Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
³ Biostatistics Unit, Rambam Health Care Campus, Haifa, Israel.
⁴ Department of Hematology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
⁵ Hematology Unit, Meir Medical Center, Kfar Saba, Israel.
⁶ Hematology Unit, Sanz Medical Center, Laniado Hospital, Netanya, Israel.
⁷ Hematology Department, Sourasky Medical Center Tel Aviv, Tel Aviv, Israel.
⁸ Department of Hematology, Bnai Zion Medical Center, Haifa, Israel.
⁹ Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.

Free article

Multicenter Study

Yishai Ofran et al. Am J Hematol. 2020 Jan.

Free article

. 2020 Jan;95(1):E3-E5.

doi: 10.1002/ajh.25651. Epub 2019 Oct 17.

¹ Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel.
² Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
³ Biostatistics Unit, Rambam Health Care Campus, Haifa, Israel.
⁴ Department of Hematology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
⁵ Hematology Unit, Meir Medical Center, Kfar Saba, Israel.
⁶ Hematology Unit, Sanz Medical Center, Laniado Hospital, Netanya, Israel.
⁷ Hematology Department, Sourasky Medical Center Tel Aviv, Tel Aviv, Israel.
⁸ Department of Hematology, Bnai Zion Medical Center, Haifa, Israel.
⁹ Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.

No abstract available

References

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1. Gianfaldoni G, Mannelli F, Baccini M, Antonioli E, Leoni F, Bosi A. Clearance of leukaemic blasts from peripheral blood during standard induction treatment predicts the bone marrow response in acute myeloid leukaemia: a pilot study. Br J Haematol. 2006;134(1):54-57.
1. Short NJ, Benton CB, Chen HC, et al. Peripheral blood blast clearance is an independent prognostic factor for survival and response to acute myeloid leukemia induction chemotherapy. Am J Hematol. 2016;91(12):1221-1226.
1. Elliott MA, Litzow MR, Letendre LL, et al. Early peripheral blood blast clearance during induction chemotherapy for acute myeloid leukemia predicts superior relapse-free survival. Blood. 2007;110(13):4172-4174.
1. Ofran Y, Leiba R, Ganzel C, et al. Prospective comparison of early bone marrow evaluation on day 5 versus day 14 of the “3 + 7” induction regimen for acute myeloid leukemia. Am J Hematol. 2015;90(12):1159-1164.