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Case Reports
. 1985 May;27(5):510-4.
doi: 10.1111/j.1399-0004.1985.tb00241.x.

A folate sensitive heritable fragile site at 19p13

N Tommerup, J Nielsen, M Mikkelsen
Case Reports

A folate sensitive heritable fragile site at 19p13

N Tommerup et al. Clin Genet. 1985 May.

Abstract

A fragile site at 19p13 was found in the mother of a newborn girl with Downs syndrome. The fragile site was expressed in medium containing low folate and by addition of FdU, whereas high folate, thymidine and thymidine-analogues inhibited the expression. This fragile site may prove valuable for linkage studies on chromosome 19.

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