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. 2019 Dec;138(6):1091-1092.
doi: 10.1007/s00401-019-02081-1. Epub 2019 Oct 8.

A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration

Jason Chiang  1 , Julie H Harreld  2 , Christopher L Tinkle  3 , Daniel C Moreira  4 , Xiaoyu Li  1 , Sahaja Acharya  3 , Ibrahim Qaddoumi  4 , David W Ellison  5
Affiliations

A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration

Jason Chiang et al. Acta Neuropathol. 2019 Dec.
No abstract available

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Figures

Figure 1.
Figure 1.
(a) Proportions of AGs or DAs with specific MYB or MYBL1 gene fusion partners. (b) t-SNE analysis of genomic DNA methylome of MYB/MYBL1-altered diffuse gliomas. AG: MYB-altered angiocentric glioma, Cb: cerebellum, DA: MYB-altered diffuse astrocytoma, DNET: dysembryoplastic neuroepithelial tumor, G34R: H3F3A G34R-mutant high-grade glioma, GG: ganglioglioma, HYPO: hypothalamus, IDH_A: IDH-mutant astrocytoma, IDH_O: IDH-mutant and 1p/19q-codeleted oligodendroglioma, K27M: H3 K27M-mutant diffuse midline glioma, PA_CB: cerebellar pilocytic astrocytoma, PA_Cx: cortical pilocytic astrocytoma, PA_HT: hypothalamic pilocytic astrocytoma, PXA: pleomorphic xanthoastrocytoma, RNGT: rosette-forming glioneuronal tumor, SEGA: subependymal giant cell astrocytoma, WM: cerebral white matter.
See this image and copyright information in PMC

References

    1. Blumcke I, Luyken C, Urbach H, Schramm J, Wiestler OD (2004) An isomorphic subtype of long-term epilepsy-associated astrocytomas associated with benign prognosis. Acta Neuropathol 107: 381–388 Doi 10.1007/s00401-004-0833-3 - DOI - PubMed
    1. Cancer Genome Atlas Research N, Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, et al. (2015) Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas. N Engl J Med 372: 2481–2498 Doi 10.1056/NEJMoa1402121 - DOI - PMC - PubMed
    1. Ellison DW, Hawkins C, Jones DTW, Onar-Thomas A, Pfister SM, Reifenberger G, Louis DN (2019) cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAF(V600E) mutation. Acta Neuropathol 137: 683–687 Doi 10.1007/s00401-019-01987-0 - DOI - PubMed
    1. Qaddoumi I, Orisme W, Wen J, Santiago T, Gupta K, Dalton JD, Tang B, Haupfear K, Punchihewa C, Easton J, et al. (2016) Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology. Acta Neuropathol 131: 833–845 Doi 10.1007/s00401-016-1539-z - DOI - PMC - PubMed

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