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Comment
. 2019 Oct 9;26(4):445-446.
doi: 10.1016/j.chom.2019.09.010.

Learning from Antibodies: Phage Host-Range Engineering

Justen Russell  1 , David Bikard  2
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Learning from Antibodies: Phage Host-Range Engineering

Justen Russell et al. Cell Host Microbe. .
Free article

Abstract

In a recent Cell paper, Yehl et al., 2019 find that bacteriophage T3 binds its host via four distal loops on the tail fiber. Randomization of these regions yield bacteriophage libraries capable of infecting resistant bacteria and preventing further resistance. These strategies may generate phage capable of infecting new hosts.

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