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. 2019 Dec;72(12):986-990.
doi: 10.1038/s41429-019-0239-z. Epub 2019 Oct 10.

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Kai Yamamoto #  1   2 , Yushi Futamura #  1 , Rachael A Uson-Lopez  1 , Harumi Aono  1 , Takeshi Shimizu  1 , Hiroyuki Osada  3   4
Affiliations

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Kai Yamamoto et al. J Antibiot (Tokyo). 2019 Dec.

Abstract

A new antifungal compound YO-001A was found from the culture broth of Streptomyces sp. YO15-A001, which was isolated from a soil sample collected in Toyama Prefecture. YO-001A was identified through morphological changes-based screening of the rice blast fungus, Pyricularia oryzae (P. oryzae). YO-001A is a new 26-membered macrolide of the oligomycin family, which exhibits potent antifungal activity against P. oryzae with an IC50 of 0.012 µM by disrupting mitochondrial respiration via inhibition of the FOF1-ATPase activity.

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