Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 8;48(D1):D9-D16.
doi: 10.1093/nar/gkz899.

Database resources of the National Center for Biotechnology Information

Eric W Sayers  1 , Jeff Beck  1 , J Rodney Brister  1 , Evan E Bolton  1 , Kathi Canese  1 , Donald C Comeau  1 , Kathryn Funk  1 , Anne Ketter  1 , Sunghwan Kim  1 , Avi Kimchi  1 , Paul A Kitts  1 , Anatoliy Kuznetsov  1 , Stacy Lathrop  1 , Zhiyong Lu  1 , Kelly McGarvey  1 , Thomas L Madden  1 , Terence D Murphy  1 , Nuala O'Leary  1 , Lon Phan  1 , Valerie A Schneider  1 , Françoise Thibaud-Nissen  1 , Bart W Trawick  1 , Kim D Pruitt  1 , James Ostell  1
Affiliations

Database resources of the National Center for Biotechnology Information

Eric W Sayers et al. Nucleic Acids Res. .

Abstract

The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts published in life science journals. The Entrez system provides search and retrieval operations for most of these data from 35 distinct databases. The E-utilities serve as the programming interface for the Entrez system. Custom implementations of the BLAST program provide sequence-based searching of many specialized datasets. New resources released in the past year include a new PubMed interface, a sequence database search and a gene orthologs page. Additional resources that were updated in the past year include PMC, Bookshelf, My Bibliography, Assembly, RefSeq, viral genomes, the prokaryotic genome annotation pipeline, Genome Workbench, dbSNP, BLAST, Primer-BLAST, IgBLAST and PubChem. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Annual growth rates of the number of records in each Entrez database as of 4 September 2019.
Figure 2.
Figure 2.
Featured result box that appears above standard sequence search results in response to the query class A beta lactamase.
Figure 3.
Figure 3.
Gene ortholog page for DNAH9. The hover box displayed shows conserved domains within the human protein NP_001363.2.
See this image and copyright information in PMC

References

    1. Schuler G.D., Epstein J.A., Ohkawa H., Kans J.A.. Entrez: molecular biology database and retrieval system. Methods Enzymol. 1996; 266:141–162. - PubMed
    1. Sayers E.W., Cavanaugh M., Clark K., Ostell J., Pruitt K.D., Karsch-Mizrachi I.. GenBank. Nucleic Acids Res. 2019; 47:D94–D99. - PMC - PubMed
    1. Harrison P.W., Alako B., Amid C., Cerdeno-Tarraga A., Cleland I., Holt S., Hussein A., Jayathilaka S., Kay S., Keane T. et al. .. The European Nucleotide Archive in 2018. Nucleic Acids Res. 2019; 47:D84–D88. - PMC - PubMed
    1. Kodama Y., Mashima J., Kosuge T., Ogasawara O.. DDBJ update: the Genomic Expression Archive (GEA) for functional genomics data. Nucleic Acids Res. 2019; 47:D69–D73. - PMC - PubMed
    1. Karsch-Mizrachi I., Takagi T., Cochrane G. International Nucleotide Sequence Database Collaboration . The international nucleotide sequence database collaboration. Nucleic Acids Res. 2018; 46:D48–D51. - PMC - PubMed

Publication types